摘要
目的：分析甲状腺乳头状及滤泡状癌的疗效及相关因素。方法：1987年9月至1995年6月我院收治甲状腺乳头状及滤泡状癌患者76例，均行手术治疗，其中行术后放疗20例、术后化疗5例。结果：年龄＜40及≥40病例的5、8年生存率分别为91．1％、91．1％及71．4％、462％，P＜0．05；Ⅰ－Ⅱ期和Ⅲ－Ⅳ期病例的5、8年生存率分别为83．6％、69．8％和64．6％、50．5％，P＜0．05。腺叶切除加放疗病例（术后残余癌6例）的局部复发率为6．3％（1／16）；腺叶切除后未放疗病例（术后残余癌1例）的局部复发率为38．1％（8／21），P＝0．06。结论：单因素分析示生存率与年龄及分期密切相关，但经Cox比例风险模型分析未能得出阳性结果;腺叶切除后行放疗对降低局部复发率可能有帮助。
Purpose:To analyze the treatment results of papillay and follicular thyroid carcinoma. Methods: 76 patients with papillay and follicular thyroid carcinoma were treated from September, 1987 to June, 1995. Among 76 surgical treated PatientS, 20 patients received postoperative radiotherapy (RT), 5 patients received postoperative chemotherapy.Results: The 5-. 8-year survival rates of patients age<40 and ≥40 were 91.1%. 91.1% and 71. 4%. 46. 2% rerespectively, P<0.05; the 5-.8-year survivals for stage Ⅰ ~Ⅱ and Ⅲ ~Ⅳ were 83. 6% .69. 8% and 64. 6% .50. 5% respectively, P<0.05. Local recurrence rate was 6. 3% (1/16) for patients treated with lobectomy+RT; and 38. 1% (8/21) for patients treated with lobectomy alone, P=0.06. Conclusion:For papillary and follicular thyroid carcinoma, stage and age were significant prognostic factors for survival by univariate analysis, but were not significant by Cox propor tional hazards model analysis; Lobectpomy plus RT can possibly reduce the local recurrence rate.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1999年第1期61-63,共3页
Chinese Journal of Cancer
