摘要
目的 探讨血清Ⅳ型胶原肽对肝纤维化诊断的应用价值。方法 用放射免疫法测定 164例各种病毒性肝炎患者及 3 0例健康献血者血清Ⅳ型胶原肽水平 ,其中有 66例慢性病毒性肝炎患者做了肝穿刺活检。通过比较各组病毒性肝炎之间及健康献血者血清Ⅳ型胶原水平差异 ,并结合病理结果分析。结果 肝硬化患者血清Ⅳ型胶原肽水平明显高于其它病毒性肝炎患者及健康对照组 ,相互比较差异有显著性 (P <0 .0 5 )。急性肝炎组、慢性肝炎轻、中度组及健康对照组之间血清Ⅳ型胶原水平没有差异。血清Ⅳ型胶原肽水平与肝纤维化程度明显相关 ,在S4阶段水平最高 ,但与肝内炎症、坏死程度无明显关系。结论 动态测定血清Ⅳ型胶原肽可以作为反映肝纤维化一项有意义的指标。
Objective To study the clinical significance of serum type Ⅳ collagen (ⅣC) level for the diagnosis of hepatic fibrosis. Methods Serum content of ⅣC was measured in 164 patients with various viral hepatitis and 30 healthy blood donors by radioimmunoassay, among them, percutaneous liver biopsy was performed in 66 patients with chronic viral hepatitis. Serum ⅣC level was analysed between various groups hepatitis and controls, and then compared to the hepatic histologic findings. Results Serum ⅣC level was significantly higher in liver cirrhosis than that in healthy controls and patients with any other hepatitis ( P <0.05), There was no significant difference in serum ⅣC level between the acute viral hepatitis, chronic mild hepatitis and controls. The serum level of ⅣC was correlated with the stages of fibrosis and to be the highest level in stage 4, but not correlated with the grades of inflammation and necrosis of the liver. Conclusion Ⅳ collagen determinations in serum may be useful for the diagnosis of hepatic fibrosis and may provide relatively noninvasive means of following disease progression.
出处
《广东医学》
CAS
CSCD
1999年第2期103-104,共2页
Guangdong Medical Journal
