摘要
背景:内皮祖细胞由于其高增殖潜能和多向分化性,近年来在治疗血管相关疾病方面的应用研究广泛开展。目的:总结内皮祖细胞在治疗血管相关疾病应用方面的研究进展。方法:应用计算机检索2004-01/2009-09PubMed数据库相关文章,检索词为"endothelial progenitor cells,vascular-related disease",并限定文章语言种类为English。同时计算机检索2004-01/2009-09清华同方数据库相关文章,检索词为"内皮祖细胞,血管相关疾病",并限定文章语言种类为中文。由第一作者和第二作者对文献根据纳入及排除标准进行分类筛选,符合研究目的者对其内容、结果进行评价。最终纳入30篇文献。结果与结论:内皮祖细胞是血管内皮细胞的前体细胞。目前已被证实内皮祖细胞不仅参与人胚胎血管发生,同时也参与出生后的血管新生。正常情况下内皮的损伤与周围成熟内皮细胞和内皮祖细胞对血管内皮的修复处于一种动态平衡状态;病理状态下,内皮祖细胞增殖并向外周血定向迁移、黏附功能减弱,导致血管内皮损伤不可修复甚至加重,从而成为许多血管相关疾病重要的致病因素之一。内皮祖细胞在治疗血管相关疾病方面有着很大的应用价值和前景,值得进一步深入研究与开发。
BACKGROUND：Endothelial progenitor cells have been extensively applied to the treatment of vascular-related diseases in recent years,due to its high proliferation potential and multidirectional differentiation.OBJECTIVE：To summarize the research progress of endothelial progenitor cells in treatment of vascular-related diseases.METHODS：We retrieved PubMed Database for relevant articles published from January 2004 to September 2009.The key words were ＂endothelial progenitor cells,vascular-related disease＂ in English.Simultaneously,a computer-based search was performed in Tsinghua Tongfang Full Text Database for relevant articles published from January 2004 to September 2009.The key words were ＂endothelial progenitor cells,vascular-related disease＂ in Chinese.The literatures were classified according to inclusion and exclusion criteria by the first and second authors.Its contents and results were evaluated.Finally,a total of 30 articles were included. RESULTS AND CONCLUSION：Endothelial progenitor cells are a vascular endothelial precursor cells.It has been confirmed that endothelial progenitor cells are not only involved in vasculogenesis in embryonic period,but also participate in angiogenesis after birth.It is in a dynamic equilibrium state between endothelial damage and the repair effects of surrounding mature endothelial cells and endothelial progenitor cells to vascular endothelial in normal circumstances.In pathological conditions,the function of proliferation and migration,adhesion of endothelial progenitor cells are all weaker than before,leading to that vascular endothelial injury cannot be repaired or damaged,thus become an important dangerous factor in many vascular-related diseases.Endothelial progenitor cells have great application value and prospect in treatment of vascular-related diseases and deserve further investigations.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2010年第27期5103-5106,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
