摘要
采用化学分离与Ames试验相结合的方法,研究了上海市飘尘中粗提物5个有机组分的致突变性。结果表明,其中以极性化合物(F_3)组分致突变性最强,约占76％～86％;其次为有机碱(F_2)化合物组分,占10％～19.6％;多环芳烃化合物(包括Bap)组分致突变性最小,仅占2.6％～11％;脂肪烃(F_4)没有致突变性;F_1主要组分有机酸,在25μg/皿低剂量时,仍出现抑菌现象,其致突变性尚准确定。研究结果提示了环境致癌因子的来源。
In this paper, a result of mutagenic effect of different fractions isolated from air particulates in Shanghai was reported. It was demonstrated that the polar compounds had a strongest mutagenicity than all other components, and accounted for 76～86% of mutagenic intensity, the alkali part mainly composed of organic alkaloids showed a second order of mutagenic intensity equivalent to a ratio of 10～19.6%, while the aromatic hydrocarbons.included PAH as well as benzopyrene only showed a weak portion equivalent to 2.6～11% of mutagenic intensity in whole mutagenic constituents. Whether the acidic part separated from air particulates had a mutagenic effect was not demonstrated, because this part showc~ an inhibitory action to Salmonella strains even the dose was lowered to the amount of 2o μg,disc. As to aliphatic components, no mutagenic effect was observed in Ames assay.
出处
《上海环境科学》
CAS
CSCD
1990年第12期18-22,共5页
Shanghai Environmental Sciences
