摘要
目的:研究曲美他嗪治疗ST段抬高型急性心肌梗死的心功能疗效。方法:入选200例ST段抬高型急性心肌梗死患者,经过溶栓等再灌注治疗,病情稳定(7～10)天后行冠状动脉造影检查结果阴性(主支血管狭窄50%以下)的患者,在常规治疗基础上随机分为治疗组和对照组,对照组按照临床需要给予硝酸脂类,ACEI,B-R阻滞剂,他汀类等药物,治疗组在此基础上给予盐酸曲美他嗪(TMZ,商品名万爽力)20mg,3次/天,疗程8周,对比两组病人在临床活动耐量及心功能方面变化,评价治疗效果。结果:急性心肌梗死患者在常规治疗基础上加曲美他嗪后与对照组相比心功能明显改善(P<0.01),6分钟步行实验距离明显延长(p<0.01),且该药有良好的耐受性和安全性。结论:曲美他嗪能通过优化心肌能量代谢达到改善生活质量和延缓心力衰竭的进展,预示着能进一步降低死亡率,提高生存率。
Objective：To study the effect of Trimetazidine for ST-segment elevation acute myocardial infarction heart function. Methods：Selected 200 patients with ST-segment elevation acute myocardial infarction,who had accepted thrombolysis and other reperfusion therapy, and whose coronary angiography results negative when they were in 7 to 10 days stable disease（the main vessel stenosis 50%）,the patients were randomly divided into treatment and control groups,two group were given the conventional therapy,the control group gave nitric acid salts, ACEK B-R blockers, statins and other drugs according to clinical,On this basis,the treatment group were given trimetazidine hydroehloride（TMZ,trade names million Shuang force）20 mg^3 times a day,8 weeks.Compared two groups of patients in clinical exercise tolerance and cardiac function changes,to evaluation of treatment.Results：Patients with acute myocardial infarction on the basis of conventional therapy plus trimetazidine compared with the control group after the marked improvement in cardiac function（P〈0.01）,6-minute walk test distance was significantly longer（P〈0.01）,and the drug has a good tolerability and safety.Conclusion：Trimetazidine on myocardial energy metabolism through the optimization to improve the quality of life and delay the progress of heart failure,suggesting further reduce mortality, improve survival rate.
出处
《中国医药导刊》
2010年第7期1180-1181,共2页
Chinese Journal of Medicinal Guide
基金
河北省廊坊市科学技术研究与发展指导计划(2009013053)
关键词
曲美他嗪
急性心肌梗死
冠状动脉造影
心肌再灌注
心功能
Trimetazidine
Acute myocardial infarction
Coronary angiography
Myocardial reperfusion
Cardiac function
