摘要
目的:探讨波生坦对大鼠颈动脉再狭窄的预防作用及与血清血管内皮生长因子(VEGF)水平的关系。方法:36只Wistar大鼠随机分为假手术组,损伤组和波生坦组。损伤组及波生坦组模拟临床PTCA过程行左颈总动脉球囊损伤,波生坦组给予波生坦100mg/kg·d灌胃(术前1天直至处死)。在此基础上观测术后7天、14天时内膜面积管腔狭窄指数,并于术前及术后1周测定血清VEGF水平。结果:波生坦组术后14天血管内膜面积及管腔狭窄指数显著低于损伤组(P<0.001)。术后7天损伤组、波生坦组血清VEGF水平较术前显著升高;波生坦组VEGF增幅高于损伤组,且术后7天血清VEGF水平与管腔狭窄指数呈线性负相关。结论:波生坦组可通过抑制血管内膜过度增生、升高血清VEGF水平预防再狭窄,有利于术后血管再内膜化。
Objective： To investigate the effect of Bosentan on carotid artery restenosis in rat and correlation of serum vascular endothelia growth factor （VEGF）.Methods： 36 Wistar rats were divided randomly into 3 groups ： control group ,injured group and Bosentan group. Bosentan was administrated intragastricly to rats of Bosentan group .The balloon catheter injury was performed on left common carotid artery of rat by imitating the process of angioplasty. After 7days, 14days neointimal area（N/A） and stenosis index（SI） was calculated. Before and 7 days after balloon injury, serum VEGF were detected. Results： NIA and SI of Bosentan group were significantly decreased compared with injury group（P〈0.001）, Serum VEGF level significantly increased 7days after balloon injury both in injure group and Bosentan group. The increase rang in Bosentan group was higher than that in injury group（P〈0.01）. The serum VEGF level 7 days after injury had linearly negatiuve correlation with SI. Conclusion： Bosentan is effective on artery restenosis by inhibiting neointimal hyperplasis and increasing the serum VEGF level.
出处
《中国医药导刊》
2010年第6期1010-1011,共2页
Chinese Journal of Medicinal Guide
