摘要
目的：探讨神经肽Ｙ（ＮＰＹ）在心血管疾病发病中的病理生理作用。方法：用放免分析法对原发性高血压、冠状动脉粥样硬化性心脏病（冠心病）、充血性心力衰竭患者治疗前后血中ＮＰＹ的含量进行测定和对比研究。结果：３种疾病患者血浆中ＮＰＹ含量分别为（３０．７１±２．９７）ｐｍｏｌ／Ｌ，（３２．６２±１１．３１）ｐｍｏｌ／Ｌ和（３４．８３±８．２６）ｐｍｏｌ／Ｌ，明显高于正常对照组（１７．３７±５．０８）ｐｍｏｌ／Ｌ，Ｐ＜０．０１；原发性高血压、充血性心力衰竭组患者血浆中ＮＰＹ的含量与疾病的程度正相关（ｒ＝０．５７３，Ｐ＜０．０５；Ｆ＝９．１２，Ｐ＜０．０１）。结论：ＮＰＹ在心血管疾病发生、发展过程中发挥着重要的作用；ＮＰＹ作为一种监测指标对心血管系统疾病病情的评估可能具有重要的意义。
Objective:To investigate the pathophysiology of neuropeptide Y (NPY) in cardiovascular diseases.Methods:Radioimmunoassay was used to determine plasma NPY levels before and after treatment in patients with essential hypertension,coronary heart disease and congestive heart failure.Results:The plasma NPY levels were elevated in patients with essential hypertension,coronary heart disease and congestive heart failure (30 71±2 97)pmol/L,(32 62±11 31)pmol/L,and (34 83±8 26)pmol/L,respectively compared with control subjects (17 37±5 08)pmol/L, P <0 01 .There was a close relationship between the severity of essential hypertension,congestive heart failure and pasma NPY levels ( r =0 573, P <0 05; F =9 12, P <0 01).Conclusions:NPY might be involved in the pathophysiology of cardiovascular diseases.Plasma NPY levels could be taken as a prognostic indicator in patients with cardiovascular diseases.
出处
《中国危重病急救医学》
CAS
CSCD
1999年第1期32-33,共2页
Chinese Critical Care Medicine
基金
第三军医大学科研基金
关键词
神经肽Y
高血压
冠心病
心力衰竭
neuropeptide Y\ \ essential hypertension\ \ coronary heart disease\ \ congestive heart failure
