2Means T K, Golenboxk D T, Feton M J. Structure and function of Toll-like receptor proteins[J]. Life Sci, 2000, 68(3): 241-258.
3Medzhitov R, Preston-Hurburt P, Janeway C A Jr. A human homologue of the Drosophila Toll protein signals activation of adaptiveimmunity[J]. Nature, 1997, 388: 394.
4Rock F L, Hardium G, Timans J C, etal. A family of human receptor structurally related to Drosophila Toll[J]. Proc Natl Acad Sci USA, 1998, 95: 588.
5Zhang DG, Zhang M S, Hayden M B, etal. A Toll like receptor that prevents infection by uropathogenic bacteria[J].Science, 2004, 303:1522-1526.
6Hyung S Y, Joo Y L, Katherine A F, etal. Specific inhibition of MyD88 independent signaling pathways of TLR3 and TLR4 by resveratrol: molecular targets are TBK1 and RIP1 in TRIF complex[J].The Journal of Immunology, 2005, 175: 3339- 3346.
7Kirschning C J, Wesche H, Augres J M, et al. Human TLR2 confers responsiveness to bacterial LPS[J].J Exp Med, 1998, 188(11): 2091-2097.
8Chow J C, Young D W, Golenbock D T, et al. TLR4 mcdi ates LPS induced signal transduction[J].J Biol Chem, 1999, 274(16) : 10689-10692.
9Tobas P S, Tapping R I, Gegner J A. Endotoxin interactions with lipopolysaccharide responsive cells[J]. Clin Infect Dis, 1999, 28:476-481.
10Jack R S, Fan X, Bernheiden M, et al. Lipopolysaccharidebinding protein is required to combat a murine gram-negative bacterialinfection[J].Nature, 1997, 389(6652):742-745.
2Zemke D,Smith JL,Reeves MJ,Majid A.Ischemia and ischemic tolerance in the brain:an overview[J].Neurotoxicology,2004,25(6):895-904.
3Kariko K,Weissman D,Welsh FA.Inhibition of toll-like receptor and cytokine signaling-a unifying theme in ischemic tolerance[J].J Cereb Blood Flow Metab,2004,24(11):1288-304.
4Fan H,Cook JA.Molecular mechanisms of endotoxin tolerance[J].J Endotoxin Res,2004,10(1):71-4.
5Aderem A,Ulevitch RJ.Toll-like receptors in the induction of the innate immune response[J].Nature,2000,406:782-7.
6Bastide M,Gele P,Petrault O et al.Delayed cerebrovascular protective effect of lipopolysaccharide in parallel to brain ischemic tolerance[J].J Cereb Blood Flow Metab,2003,23(2):399-05.
7Langdale LA,Kajikawa O,Frevert C et al.Sustained tolerance to lipopolysaccharide after liver ischemia-reperfusion injury[J].Shock,2003,19(4):553-8.
8Yoshimura A,Mori H,Ohishi M et al.Negative regulation of cytokine-signaling influences inflammation[J].Curr Opin Immunol,2003,15(6):704-8.
9Cui X,Rouhani FN,Hawari F et al.Shedding of the type II IL-1 decoy receptor requires a multifunctional aminopeptidase,aminopeptidase regulator of TNF receptor type 1 shedding[J].J Immunol,2003,171(12):6814-9.
10Mantovani A,Locati M,Polentarutti N et al.Extracellular and intracellular decoys in the tuning of inflammatory cytokines and Toll-like receptors:the new entry TIR8/SIGIRR[J].J Leukoc Biol,2004,12(1):12.
