期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

抗β2-糖蛋白Ⅰ抗体与先兆流产的关系 被引量：5

在线阅读 下载PDF
导出
摘要 目的探讨抗β2-糖蛋白Ⅰ抗体与先兆流产的关系。方法通过酶联免疫吸附试验(ELISA)检测121例先兆流产孕妇(其中妊娠未成功者75例,妊娠成功者46例)、40名健康正常妇女(其中未妊娠者20名,妊娠者20名)的血清中抗β2-糖蛋白Ⅰ抗体(IgM型)的水平。结果先兆流产组血清抗β2-糖蛋白Ⅰ抗体总阳性率为58.7%,与对照组(17.5%)相比,差异有统计学意义(P<0.05)。妊娠未成功组阳性率为78.7%,与妊娠成功组(26.1%)比较,差异有统计学意义(P<0.05);妊娠未成功组与对照组比较,差异有统计学意义(P<0.05),而妊娠成功组与对照组相比,差异无统计学意义(P>0.05);首次先兆流产组、多次先兆流产组抗β2-糖蛋白Ⅰ抗体阳性率均高于健康正常妊娠组(P<0.05),而不同次数先兆流产组间阳性率差异无统计学意义(P>0.05)。结论先兆流产与体内抗β2-糖蛋白Ⅰ抗体的存在有关,检测抗β2-糖蛋白Ⅰ抗体可为先兆流产的诊断、治疗及预后判断提供实验室依据。
作者 潘婉仪 丁海明 周华友
机构地区 广东省中医院检验科
出处 《检验医学》 CAS 北大核心 2010年第7期569-571,共3页 Laboratory Medicine
关键词 抗β2-糖蛋白Ⅰ抗体 先兆流产 自身免疫
分类号 K446.62 [历史地理—世界史]
  • 相关文献

参考文献5

  • 1Meroni PL,Raschi E,Tostoni C,et al.Statins prerenten-dothelial cell activation incluced by antiphospholipid anti-β2-glycoprotein antibodies:effect on the proadhesiveand proinflammotory phenotype[J].Arthitis Rheum,2001,4(12):2870-2878.
  • 2刘静珠,林丽,胡静,张士平,张爽,樊静.抗β_2-糖蛋白Ⅰ抗体与反复自然流产的关系[J].吉林大学学报（医学版）,2006,32(3):486-488. 被引量：8
  • 3Matsuura E,Kobayashi K,Kasahara J,et al.Anti-beta-2 glycoprotein I autoantibodies and atherosclerosis[J].Int Rev Immunol,2002,21(1):51-66.
  • 4Chamley LW,Allen JL,Johnson PM.Synthesis of beta 2 glycoprotein 1 by the human placenta[J].Placenta,1997,18(5-6):403-410.
  • 5Di Simone N,Raschi E,TestoniC,et al.Pathogenic role of anti-beta2-glycoprotein I antibodies in antipho-spholipid associated fetal loss:characterisation of beta 2-glycoprotein I binding to trophoblast cells and functional effects of anti-beta 2-glycoprotein I antibodies in vitro[J].Ann Rheum Dis,2005,64(3):462-467.

二级参考文献6

  • 1路春梅,刘晶珠,李荷莲,林丽,毛跃平,张爽.抗心磷脂抗体及抗核抗体与反复自然流产的关系[J].吉林大学学报（医学版）,2005,31(1):111-113. 被引量：8
  • 2Christiansen OB. A fresh look at the cause and treatment of recurrent miscarriage, especially its immunological aspects [J]. Hum Reproduc, 1996, 2:270-276.
  • 3Ailus K, Tulppala M, Palosuo T, et al. Antibodies to beta 2-glycoprotein I and prothrombin in habitual abortion [J]. Fertil Steril, 1996, 66 (6): 937-941.
  • 4Reshetniak TM, Alekberova ZS, Aleksandrova EN. Clinico-immunological aspects of antiphospholipid syndrome [J].Vestn Ross Akad Med Nauk, 2003, (7):31-34.
  • 5Jacob H. Rand molecular pathogenesis of the antiphospholipid syndrome [J]. Circulation Research, 2002, 90:29.
  • 6Simone ND, Raschi E, Testoni C, et al. Pathogenic role of anti-β2-glycoprotein I antibodies in antiphospholipid associated fetal loss: characterisation of β2-glycoprotein I binding to trophoblast ceils and functional effects of anti-β2-glycoprotein I antibodies in vitro [J]. Ann Rheum Dis, 2005, 64: 462-467.

共引文献7

同被引文献54

  • 1沈歈忱,孟文珍,罗军,陈水娟.抗β_2糖蛋白1抗体与习惯性流产[J].中国妇产科临床杂志,2004,5(2):103-105. 被引量：6
  • 2路春梅,刘晶珠,李荷莲,林丽,毛跃平,张爽.抗心磷脂抗体及抗核抗体与反复自然流产的关系[J].吉林大学学报（医学版）,2005,31(1):111-113. 被引量：8
  • 3常笑雪,黄鹂,杨石强,赵荣坡,张鑫.早期自然流产的免疫学因素研究与分析[J].中国妇幼保健,2005,20(16):2036-2037. 被引量：32
  • 4刘静珠,林丽,胡静,张士平,张爽,樊静.抗β_2-糖蛋白Ⅰ抗体与反复自然流产的关系[J].吉林大学学报（医学版）,2006,32(3):486-488. 被引量：8
  • 5Meroni PL,Raschi E,Tostoni C,et al. Statins preventendothelial cell activation induced by antiphospholipid(anti-beta2-glycoprotein I) antibodies: effect on theproadhesive and proinflammatory phenotype [J]. Ar-thritis Rheum,2001,44(12) :2870-2878.
  • 6Di Simone N> Raschi E, Testoni C,et al. Pathogenicrole of anti-beta2-g!ycoprotein I antibodies in an-tiphospholipid associated fetal loss : characterisation ofbeta2-glycoprotein I binding to trophoblast cells andfunctional effects of anti-beta2-glycoprotein I antibod-ies in vitro [J]. Ann Rheum Dis,2005,64 (3):462-467.
  • 7Izumi T, Pound ML, Su ZW, et al. Anti-p2-glycopro-tein I antibody-mediated inhibition of activated proteinC requires binding of |32-glycoprotein I to phospholip-ids[J]. Thrombosis and Haemostasis,2002,88 (4):620-626.
  • 8Carmo-Pereira S,Bertolaccini ML, Escudero-Contr-eras A,et al. Value of IgA anticardiolipin and anti-be-ta2-glycoprotein I antibody testing in patients withpregnancy morbidity [J]. Ann Rheum Dis, 2003,62(6):540-543.
  • 9Zammiti W, Mtiraoui N?Kallel C,et al. A case-controlstudy on the association of idiopathic recurrent preg-nancy loss with autoantibodies against beta2-glyco-protein I and annexin V[J]. Reproduction,2006, 131(4):817-822.
  • 10Murray Adams.Measurement of Lupus Anticoagulants: An Update on Quality in Laboratory Testing[J].Semin Thromb Hemost.2013(03)

引证文献5

二级引证文献19

检验医学
2010年 第7期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部