摘要
目的：探讨细胞间隙连接蛋白Cx32在肝细胞肝癌（hepatocellularcarcinoma,HCC）及其癌旁肝、肝硬变（livercirrhosis，LC）、病毒性肝炎（viralhepatitis，VH）和正常肝组织中的表达和意义。方法：应用SP免疫组织化学法检测Cx32在47例HCC及其15例癌旁肝、19例LC、8例VH及和9例正常肝组织中的表达。结果：Cx32蛋白表达既定位于肝细胞胞浆中，又定位于胞膜上，也可二者同时阳性。Cx32在HCC及癌旁肝、LC、VH和正常肝组织中阳性率分别为42．6％、73．3％、73．7％、75．0％和88．9％。X2检验，Cx32在HCC中的表达明显低于在癌旁肝、LC、VH及正常肝组织的水平（P＜0．01）。随着HCC分化程度的降低，其阳性率有所下降。结论：间隙连接蛋白Cx32表达减弱可能是HCC发生的重要环节。
Objective: To investigate the regularity and significance of expression of connexin (Cx) 32 in human hepatocellular carcinoma (HCC) and liver diseases patients. Method: Cx32 were detected in 47 cases of HCC, 19 cases of liver cirrhosis (LC), 8 cases of viral hepatitis (VH) and 9 cases of normal hepatic tissues methods: SP immunohistochemical methods was used. Results: Cx32 antigen postitive stain located not only in the cytoplasm but also on the membranes of hepatocytes. The detecition rates of Cx32 in HCC and Pericancerous liver tissue, LC, VH and normal liver tissues were 42. 6%, 73. 3%, 75. 0% and 88. 9% respectively. In Ⅰ, Ⅱ，Ⅲ histological degree of HCC the rates are 50. 0%, 42. 9% and 38. 9%. The lower the degree, the lower the Cx32 positive rate. Ch－square test suggested that Cx32 peitive rate in HCC was significant lower than that in Pericancerous liver tissur and normal liver tissues (P < 0. 01 ). Conclusion: The derease Of Cx32 may play an important role in hepatocarcinogenesis.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1999年第2期133-135,共3页
Chinese Journal of Cancer
