摘要
研究细胞间粘附分子１（ＩＣＡＭ－１）在肝癌转移过程中的作用和作为预测肝癌转移标志物的价值。方法以裸鼠人肝癌转移模型为材料，以ｄｏｔｉｍｍｕｎｏ－ｂｌｏｔ的方法测定不同生长时间肝癌组织中ＩＣＡＭ－１的表达。结果ＩＣＡＭ－１在肝癌组织中的表达与肿瘤的生长时间呈明显的正相关（ｒ＝０．８８，Ｐ＜０．０１），与肿瘤大小呈正相关（ｒ＝０．０５，Ｐ＜０．０５），在肝癌转移发生后ＩＣＡＭ－１表达突然升高，以后维持在较高水平，肿瘤转移组高于无转移组（Ｐ＜０．０１），多脏器转移组高于单脏器转移组（Ｐ＜０．０５）。结论组织中ＩＣＡＭ－１的表达可以反映裸鼠人肝癌的生长转移状态，可以作为预测其转移的标志物。
Objective To study the role of intercellular adhesion molecule-1 (ICAM-1) in theprocess of hepatocellular cancer (HCC) metastasis and the probability of ICAM-1 as a marker to predictHCC metastasis. Method Tissue ICAM-1 expression in liver cancer of different growing stages wasdetected by using dot immuoblot. Result Tissue ICAM-1 expression in liver cancer was obviously positively related with tumor growing stage (r=0. 88, P<0. 01),tumor size (r=0. 05, P<0. 01). TissueICAM-1 expression was increased suddenly when metastasis happened and then kept in high level. Tissue ICAM-1 was higher in metastasis HCC than in mon-metastasis HCC (P<0.01), higher in multisitemetastasis HCC than in monosite metastasis HCC (P<0. 05). Conclusion Tissue ICAM-1 expressioncould reflect the growth and metastasis of HCC, and might be used as a marker for HCC metastasis.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
1999年第2期155-156,共2页
Chinese Journal of Experimental Surgery
基金
美国CMB基金!93-583
国家自然科学基金!96707
国家"九五"攻关课题基金!96-906-01-15
关键词
肝肿瘤
肿瘤转移
细胞间粘附分子
Liver cancer, Tumor metastasis, Intercellular adhesion molecule-1
