摘要
了解骨纤维结构不良中癌基因蛋白的表达情况。方法应用免疫组化法对３７例骨纤维结构不良行多种癌基因蛋白检测。结果３７例实验组中ｃ－ｆｏｓ、ｃ－ｍｙｃ蛋白均有高表达（Ｐ＜０．０１）。ｒａｓｐ２１蛋白在该病恶变组中有高表达（Ｐ＜０．０５）。结论ｃ－ｆｏｓ、ｃ－ｍｙｃ蛋白过度表达在骨纤维结构不良的发生发展中起重要作用，ｒａｓｐ２１蛋白过度表达在该病的恶性变过程中起作用。本研究结果对骨纤维结构不良的诊断和治疗具有广阔的应用前景。
Objective To investigate the expression of oncoproteins of fibrous dysplasia (FD). MethodBy using immunohistochemistry method, the expression of oneoproteins in 37 patients with FD was detect ed. Result Experimental groups of 37 cases had higher positive expression of c-Fos and c-Myc (P<0.01).Malignant groups of FD had positive expression of rasP21 (P<0.05). Conclusion The overexpression of cFos and c-Myc plays a key role in the pathogenesis of FD, and increased expreesion of oncoproteins ras P21plays an important role in canceration of FD.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
1999年第2期136-137,共2页
Chinese Journal of Experimental Surgery
