摘要
目的：研究β２激动剂舒喘灵对缺氧大鼠肺动脉高压及肺β２受体ｍＲＮＡ的作用。方法：常压缺氧４周，同时用舒喘灵灌胃（５ｍｇ·ｋｇ－１·ｄ－１），用肺动脉插管测压，用ＲＴ－ＰＣＲ术测肺β２受体ｍＲＮＡ。结果：缺氧同时给舒喘灵可减轻缺氧大鼠肺动脉高压、右心室压及右心室肥厚，同时使降低的β２受体ｍＲＮＡ回升到对照水平，动脉血氧分压不受影响，对体动脉压无明显作用。结论：舒喘灵能防止缺氧引起的肺动脉高压和肺肾上腺素能β２受体ｍＲＮＡ水平的降低。
AIM:Effect of β 2 agonist salbutamol on pulmonary arterial pressure and lung β 2 adrenoceptor mRNA was investigated.METHOD:Rats underwent isobaric hypoxia for 4 weeks and salbutamol was poured into stomach(5mg·kg -1 ·d -1 )at some time.Pulmonary arterial pressure was measured.Weights of right ventricle(RV),left ventricle and septum(LV+S) were measured and RV/(LV+S) ratio was calculated.Lung β 2 adrenoceptor was measured by RT-PCR.RESULTS:Salbutamol could alleviate pulmonary arterial pressure,right ventricular pressure and right heart hypertrophy induced by hypoxia in rat.The decreased β 2 adrenoceptor mRNA recovered to normal control level at some time.No significant effect was found on arterial blood oxygen partial pressure and blood pressure.CONCLUSION:Salbutamol can alleviate pulmonary arterial pressure and right ventricular hypertrophy and the decrease of lung β 2 adenoceptor mRNA incuced by hypoxia in rat.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1999年第3期193-196,共4页
Chinese Journal of Pathophysiology
基金
国家八五攻关项目
关键词
肺动脉高压
缺氧
舒喘灵
肾上腺素能
Β2受体
Albuterol
Anoxia
Pulmonary artery
Receptors
adrenergic
beta
RNA
messenger
