摘要
目的探讨槲皮素在HPV阳性的宫颈鳞状上皮不典型增生(ASCUS)患者中的临床应用效果。方法以宫颈癌高发区湖北五峰为试验点。使用TCT和HC-2筛查高危型HPV感染阳性的ASCUS患者90名,随机选取45名为实验组,另外45名为对照组。用中药槲皮素宫颈局部上药,6个月后复查,采用TCT和HC-2检测用药前后宫颈细胞学的变化以及高危型HPV阳性患者例数的改变。结果槲皮素治疗后,经TCT筛查,实验组正常患者38例,总有效率为84.4%。对照组正常患者20例,总有效率为44.4%。比较两组间差异有统计学意义(P<0.05)。HC-2检测高危型HPV感染阳性例数的改变,实验组转阴30例,转阴率为66.7%,对照组转阴16例,转阴率为35.6%。比较两组间差异有统计学意义(P<0.05)。结论槲皮素对HPV阳性的ASCUS患者有较明显的疗效。
Objective To discuss the clinical application effect of quercetin in the HPV - positive cervical squamous epithelial dysplasia （ASCUS） patients. Methods Our test sites were in the high incidence area of cervical cancer in Hubei Wufeng. There were 90 patients in high -risk HPV - positive ASCUS infection screening by TCT and HC -2, of which 45, called the experimental group, were randomly selected,and another 45, called the control group. Traditional Chinese medicine drug quercetin was used on the cervical part, and the results were review after 6 months. The changes in cervical cytology before and after treatment, as well as the changes in the number of cases of high - risk HPV - positive patients were detected using TCT and HC - 2. Results After the treatment of quercetin, there were 38 cases in experimental group being normal by the TCT screening, and the total effective rate was 84.4% . But the control group only had 20 normal patients, with a total effective rate of 44.4%. There was statistically significant difference between the two groups （P 〈 0.05 ）. We used HC - 2 to detect high - risk HPV - positive cases of infection and observe the number of changes, and we could find that the negative cases in the experimental group were 30, negative conversion rate was 66.7% , negative cases in the control group were 16, negative conversion rate was 35.6%. There was statistically significant difference between the two groups （P 〈 0. 05 ）. Conclusion Quercetin has a more visible effect on HPV -positive ASCUS patients.
出处
《医学研究杂志》
2010年第8期54-56,共3页
Journal of Medical Research
基金
湖北省科技厅资助项目(2007AA301B33-2)
