摘要
目的：建立测定雷尼替丁血药浓度的方法。方法：采用系数倍率法。结果：能不经分离直接消除血浆的背景干扰。平均回收率为９９．０８％，在０．１～１０μｇ·ｍｌ－１浓度范围内线性良好（ｒ＝０．９９９９）。结论：方法简便、快速、经济、重复性好。适用于临床、特别是基层医疗单位的血药浓度检测和药动学研究。
OBJECTIVE:A K ratio spectrophotometry method was developed for the determination of Ranitidine in plasma.METHODS:The results showed that this method could eliminate the interference of plasma itself.RESULTS:The average recovery was 99.08% .The linear range was 0.1 ～10 μg·ml -1 r = 0.999 9 ,and detection limit was 0.1 μg·ml -1 .CONCLUSIONS:The method is simple,rapid and accurate.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
1999年第3期145-147,共3页
Chinese Journal of Hospital Pharmacy
关键词
系数倍率法
雷尼替丁
血药浓度
K ratio spectrophotometry method,ranitidine,plasma drug concentration
