摘要
１０名慢性阻塞性肺疾病（ＣＯＰＤ）患者口服两个不同剂量的茶碱，分别达到两个稳态，测定谷浓度值，同时测定最大肺活量（ＦＶＣ），一秒钟用力呼气量（ＦＥＶ１）。提高茶碱稳态浓度前后的ＦＶＣ值无显著差异，揭示在常规剂量下茶碱对ＣＯＰＤ病人通气功能的改善是有限的。引用公式：ＦＶＣ＝Ｃｓｓ×ｍ＋ｉ，预测病人ＦＶＣ值与实测值差异无显著性（Ｐ＞０．０５）。不同稳态浓度的ＦＶＣ值可用此公式预测。
patients with COPD administered orally two different theophylline dosages to two different steady states.The trough serum theophylline concentrations were measured by HPLC.Forecd vital capacity(FVC) and forced expiratory volume in one secend(FEV 1) were measured at the same time.FVC at different Cpss were not significant difference,this suggested that theophylline improving pulmonary function were not limitless at routine dosage.FVC can be described as a linear relation to Cpss:FVC=C ss ×m+i.All the predicted FVC compared with all the observed FVC were not significant difference( P > 0.2 ).FVC can be predicted at any concentration.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
1999年第3期142-144,共3页
Chinese Journal of Hospital Pharmacy
