摘要
目的：研究利福平白蛋白微球的制备和体外释放。方法：选用戊二醛为交联剂，采用聚合物分散法制备利福平白蛋白微球。结果：所得微球粒径范围为１０～３０μｍ，微球中利福平含量为２３．５±０．８％（ｗ／ｗ）。扫描电镜下观察载药微球呈圆形，但表面不光滑，有未洗脱的药物微粒存在。体外释放实验结果显示，利福平微球体外释放符合Ｈｉｇｕｃｈｉ方程，具有明显的缓释作用。结论：利福平适于制成微球制剂。
OBJECTIVE:To study the preparation and release in vitro of rifampin albumin microspheres.METHODS:Rifampin albumin microspheres(RFP MS) were prepared by polymeric dispersion method and glutaraldehyde was used as a cross linking agent.Drug release from RFP MS was performed by a dialysis system.RESULTS:The diameter of RFP MS ranged from 10 to 30 μm and the rifampin content was 23.5 ± 0.8% .Scanning electron micrography showed the RFP MS had spherical surface and some rifampin crystals were left on the RFP MS surface.The results of in vitro drug release showed that the RFP MS had a sustained release property and the release accorded with Higuchis equation.CONCLUSIONS:Microspheres are better form for rifampin.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
1999年第3期131-132,共2页
Chinese Journal of Hospital Pharmacy
基金
国家自然科学基金
关键词
利福平
白蛋白微球
制备
含量
体外释放
rifampin,albumin microsphere,preparation method,content determination,release in vitro
