摘要
目的探讨孕妇人巨细胞病毒（ｈｕｍａｎｃｙｔｏｍｅｇａｌｏｖｉｒｕｓ，ＨＣＭＶ）感染的宫内传播情况以及先天性ＨＣＭＶ感染对胎婴儿的近期影响。方法酶联免疫吸附试验（ＥＬＩＳＡ）筛查孕妇血清ＨＣＭＶ－ＩｇＭ１８８１例，聚合酶链反应（ＰＣＲ）检测血ＨＣＭＶＤＮＡ６５６例；追踪感染孕妇的胎婴儿ＨＣＭＶ感染情况和近期预后。结果孕妇ＨＣＭＶ－ＩｇＭ阳性率为２４％，ＨＣＭＶＤＮＡ阳性率为１２０％，ＨＣＭＶ宫内传播率为１７２％；有畸胎史的孕妇ＨＣＭＶ感染率显著高于无畸胎史者（Ｐ＜００１）；ＨＣＭＶ感染孕妇的胎儿宫内发育迟缓率显著高于非感染孕妇（Ｐ＜００１）；ＨＣＭＶ先天感染儿畸形率、生后发育异常率均显著高于非先天感染儿（Ｐ＜００１）。结论孕妇、胎儿ＨＣＭＶ感染可能导致畸胎、胎婴儿发育异常。
Objective\ To detect the infection and intrauterine transmission of human cytomegalovirus (HCMV) in pregnant women and study the effects of HCMV intrauterine on fetal development. Methods\ Serum HCMV-IgM were screened in 1881 pregnant women by enzyme-linked immunosorbant assay (ELISA), and among them, blood HCMV DNA were detected in 656 cases by polymerase chain reaction (PCR). 99 neonatals born by infected mother were followed-up for HCMV infection and early development. Results\ The positive rate of HCMV-IgM was 2.4%(45/1881) and that of HCMV DNA was 12.0%(79/656). The rate of HCMV intrauterine transmission was 17.2%. Pregnant women with history of teratism had significantly higher HCMV infection rate than those with normal obstetric history( P <0 01). In congenital infected babies, the rate of teratism (17.6%) and that of abnormal development (21.4%) were much higher than those of uninfected cases ( P <0.01). Incidence of intrauterin growth retardation in infected mothers was much higher than that in the controls. Conclusions\ HCMV infection in pregnancy might cause teratism and abnormal development in fetuses and newborns.
出处
《中国实用妇科与产科杂志》
CAS
CSCD
北大核心
1999年第3期166-169,共4页
Chinese Journal of Practical Gynecology and Obstetrics
关键词
巨细胞病毒
宫内传播
聚合酶链反应
ELISA
Human cytomegalovirus Intrauterine transmission Abnormal development Polymerase chain reaction Enzyme-linked immunosorbant assay
