摘要
目的探讨采用配伍方法进行药物流产后出血时间长的原因。方法一组２２例，服米非司酮（Ｒｕ４８６）及米索前列醇药物流产，二组２０例采用吸宫术终止妊娠。分别于妊囊排出或吸宫后第５、１４、２４天抽肘静脉血测血ｈＣＧ、Ｐ、Ｅ２、ＦＳＨ、ＬＨ及ＰＲＬ，同时记录出血时间。结果发现Ｒｕ４８６组血中ｈＣＧ下降缓慢，流产后１４、２４天的ｈＣＧ明显高于吸宫术组。虽然两组各时间Ｅ２值无显著性差异，但是Ｒｕ４８６组各时间的Ｅ２值均低于吸宫组。两组各时间的Ｐ、ＬＨ、ＦＳＨ、ＰＲＬ值均无显著性差异（Ｐ＞００５）。结论Ｒｕ４８６合并米索终止早孕引起出血多、时间长，与子宫蜕膜剥脱慢、ｈＣＧ下降缓慢、雌激素不足、子宫内膜修复慢有关。
Objective\ To study the causes for long time bleeding in drug induced abortion. Methods\ 42 cases were assigned randomly to two groups, 22 cases of early pregnancy were terminated by administration of Ru486 and misoprostol, and 20 cases were performed by uterine aspiration. The serum levels of hCG, E 2, P, FSH, LH and PRL were detected in all cases in the 5 th , 14 th and 24 th day after excretion of the pregnant sac or uterine aspiration,and the bleeding duration was recorded simultaneously. Results\ Serum hCG decreased slowly in Ru486 group and its levels in the 14 th and 24 th day after abortion were obviously higher than that in uterine aspiration group. Although there was no significant difference in E 2 level between the two group, the E 2 values in Ru486 group were lower than those in uterine aspiration group in the measured days. The serum levels of P, LH, FSH and PRL had no marked differences in each time ( P >0.05). Conclusions\ The long duration and large amount of bleeding in early termination of pregnancy by Ru486 combined with misoprostol were correlated with slow denudation of the uterine decidua, slow decrease of hCG, and slow endometrial repair ment by insufficient E 2.
出处
《中国实用妇科与产科杂志》
CAS
CSCD
北大核心
1999年第3期159-160,共2页
Chinese Journal of Practical Gynecology and Obstetrics
关键词
米非司酮
米索前列醇
终止妊娠
出血
Ru486 Misoprostol\ Human chorionic gonadotropin Gonadotropic hormones Estradiol Progesterone
