摘要
目的应用链激酶（ＳＫ）、重组链激酶（ｒ－ＳＫ）、尿激酶（ＵＫ）、重组组织型纤溶酶原激活物（ｒｔ－ＰＡ）溶栓治疗急性心肌梗死（ＡＭＩ）患者，比较其凝血与纤溶系统的动态变化。方法对４３例经溶栓治疗（ＳＫ８例，ｒ－ＳＫ１３例，ＵＫ１６例，ｒｔ－ＰＡ６例）的ＡＭＩ患者，分别于溶栓前后动态检测凝血酶原时间（ＰＴ）、活化的部分凝血活酶时间（ＡＰＴＴ）、纤维蛋白原（ＦＧ）、Ｄ二聚体（Ｄ－Ｄｉｍｅｒ）、纤溶酶原（ＰＬＧ）、α２抗纤溶酶（α２ＡＰ）、组织型纤溶酶原激活物（ｔ－ＰＡ）、组织型纤溶酶原激活物抑制物（ＰＡＩ－１）等指标的活性或含量。结果应用ＳＫ、ｒ－ＳＫ、ＵＫ、ｒｔ－ＰＡ溶栓治疗后，均会引起凝血活性的明显降低与纤溶活性的明显增高。ＳＫ与ｒ－ＳＫ对凝血与纤溶系统的影响略高于ＵＫ。ｒｔ－ＰＡ对ＦＧ含量影响低于另外３者（Ｐ值均＜００５）。
Objective\ To compare the activity changed of strepkinase(SK) or recombinant strepkinase (r-SK) of urokinase (UK) or recombinant tissue-type plasminogen activator(rt-PA) between coagulant and fibrinolytic systems during thrombolytic therapy for patients with acute myocardial infarction(AMI).[WT5”HZ]Methodes\ Activity or concentration of prothrombin time(PT)、activated partial thromboplasmin time(APTT)、fibrinogen(Fg)、D-Dimer、plasminogen(PLG)、α 2 antiplasmin(α 2 AP)、tissue type plasminogen activator(t-PA) and tissue-type plasminogen activator inhibitor-1(PAI-1) were examined from 43 AMI patients with thrombolytic therapy(SK 8,r-SK 13,UK 16,rt-PA 6) before and after treatment respectively.Results\ After thrombolytic therapy with SK or r-SK or UK or rt-PA,the fibrinolytic activity was significantly increased,coagulant activity was significantly decreased.The effect of SK and r-SK on coagulant and fibrinolytic systems were a little greater than that of UK.The effect of rt-PA on FG was the smallest.Conclusion\ The fibrinolytic and coagulant activity changes might influnce clinical results.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
1999年第3期153-154,共2页
Chinese Journal of Practical Internal Medicine
关键词
急性
心肌梗塞
凝血系统
纤溶系统
Coagulation\ Fibrinolysis\ Acute myocardial infarction\ Thromboltic therapy
