摘要
目的探讨成都市妊娠期糖尿病(gestational diabetes mellitus,GDM)可能相关的危险因素,为加强临床早期干预和管理提供依据。方法采用病例-对照研究方法 ,选择2008年9月～2009年6月在我院经75gOGTT诊断为GDM的患者125例及110例正常妊娠妇女,进行GDM危险因素分析。结果单因素分析发现,在孕妇体重指数、有糖尿病家族史、不良孕产史(畸形儿、巨大胎儿分娩、不明原因死胎、死产、新生儿死亡、自然流产史)、高血红蛋白血症(血红蛋白Hb>130g/L)、高脂血症[三酰甘油(TG)>1.70mmol/L]与对照组比较差异有统计学意义(P均<0.05);根据单因素分析结果 ,选择有显著意义的因素进行多因素Logistic回归分析。多因素分析发现,与成都市GDM有关的因素是孕前体重指数(BMI)、不良孕产史、家族史及高Hb血症(OR值分别为1.173,2.882,3.541,1.050)。结论成都市妊娠期糖尿病的发病可能与肥胖、糖尿病家族史、不良孕产史及高Hb血症有关。
Objective To identify the possible risk factors of gestational diabetes mellitus in Chengdu,and enhance early clinical intervention and provide a basis for management.A hospital-based pair matched case-control study was carried out in 125 patients with GDM and 110 controls.The data were analysed by univariate analysis,multi-variate conditional logistic regression.Univariate analysis showed that the positive response rates for BMI;Adverse pregnancy history;family history of diabetes;Hyperlipidemia and Hb130g/L in the GDM group were much higher than those in the control group（P0.05）.The multivariate analysis confirmed that the risk factors associated with GDM were BMI;Adverse pregnancy history,family history of diabetes and high hemoglobin（OR=1.173,2.882,3.541,1.050,respectively）.The above findings suggest that GDM may be associated with prior induced obesity,family history diabetes and high hemoglobin.
出处
《四川医学》
CAS
2010年第7期873-875,共3页
Sichuan Medical Journal
基金
四川省卫生厅科学研究项目(编号:070127)
关键词
妊娠期糖尿病
危险因素
gestational diabetes mellitus
risk factors
