摘要
目的：探讨嗅神经母细胞瘤的诊断和治疗效果。方法：２２例患者，１５例常规病理检查明确诊断，７例用ＮＳＥ、ＮＦ、ＬＣＡ、ＥＭＡ、ＣＥＡ抗体行免疫组化检查。所有病例分别采用手术、放疗、手术加放疗、手术加放疗和化疗进行治疗。结果：ＮＳＥ阳性率７／７，ＮＦ５／７，其余３种抗体检查均为阴性。１９例手术中１４例发现前颅窝底骨质破坏。随访１７例，３年、５年生存率分别为５９％和３５％。结论：免疫组化检测对本病诊断和鉴别诊断有较大帮助，病变位于鼻腔顶部且前颅窝底骨质破坏提示本病的可能。早期诊断加综合治疗能提高本病生存率。
Objective: To explore the diagnosis and treatment of olfactory neuroblastoma (ONB). Methods: Of the 22 cases with ONB, 15 cases were diagnosed with conventional light microscope, and 7 cases by immunohistochemical staining using antibody NSE, NF, LCA, EMA and CEA. All cases were treated with simple surgery, radiotherapy or combined therapy. Results: Positive NSE and NF stainings were shown in seven and five cases respectively, while none showed immunoreactivity with LCA, EMA or CEA. Bone destructions were found in anterior skull base in 14 of 19 cases during operation. 17 cases were followed up, and the three ,and five year survival rates were 59% and 35% respectively. Conclusion: Immunohistochemistry is a helpful adjutant method of diagnosis and differentiation. Focuses located at the top of the nose cavity and bone destruction in anterior skull base both in dicate the possibility of ONB. Early diagnosis and combined therapy can improve the survival rate.
出处
《中国耳鼻咽喉颅底外科杂志》
CAS
1999年第1期29-31,共3页
Chinese Journal of Otorhinolaryngology-skull Base Surgery
关键词
鼻肿瘤
嗅神经母细胞瘤
诊断
治疗
Nasal neoplasm Olfactory neuroblastoma Immunohistochemistry Diagnosis Therapy
