摘要
采用豚鼠离体心脏、兔胸主动脉条和麻醉大鼠急性降压等实验，初步观察了两种新的神经酰胺（代号分别为 Ｎ１和 Ｎ２）对心血管的药理作用。结果表明：Ｎ１和 Ｎ２（１００μｍｏｌ／Ｌ，２００μｍｏｌ／Ｌ），对豚鼠离体心脏收缩力和心率都具有明显的抑制作用。但Ｎ１和Ｎ２（２００μｍｏｌ／Ｌ）均不能阻断ＩＳＯ和ＮＡ增加豚鼠离体心脏收缩力和心率的作用。５０μｍｏｌ／Ｌ和１００μｍｏｌ／Ｌ的Ｎ１或Ｎ２对兔胸主动脉条无作用，对ＫＣＩ和Ａｄｒ诱发的主动脉条收缩也无影响。静注１．ｍｇ／ｋｇ和３．２ｍｇ／ｋｇ的Ｎ１或Ｎ２对麻醉大鼠具有急性降压作用，阿托品可阻断其降压作用。提示Ｎ１和Ｎ２的药理作用可能与Ｍ受体有关。
The cardiovascular pharmacological actions of two new ceramides (N1 and N2) were studied. Isolated guinea-pig hearts test, Isolated rabbit aortic strips test and hypotensive test on anesthetized rats were used. The results indicated that N1 and N2 (100βmol/L, 200βmol/L)could obviously inhibit the contractive force and the heart rate of isolated guinea-pig hearts. But N1 and N2 (200βmol/L)couldn' t eliminate the excitatory action of Iso and NA on isolated guinea-pig hearts. N1 and N2 (50βmol/L, 100βmol/L)had no effects on isolated aortic strips of rabbits and the contraction of aortic strips induced by KCI or Adr. N1 and N2 (iv 1. 6mg/kg 3. 2ing/kg)had hypotensive action in anesthetized rats, but the hypotensive action of N1 or N2,could be antagonized by atropine. The results suggested that the pharmacological action of N1 and N2 might be related to Mcholino-receptor.
出处
《中国海洋药物》
CAS
CSCD
1999年第1期16-19,共4页
Chinese Journal of Marine Drugs
关键词
神经酰胺
降压药
大鼠
药理作用
Ceremides (N1 and N1 )
aortic strips
isolated heart
blood pressure.
