摘要
目的探讨血浆血栓调节蛋白（ＴＭ）在糖尿病性肾病患者中的变化以了解其在微血管病变发病中的意义。方法检测５８例２型糖尿病患者血浆ＴＭ与内皮素（ＥＴ）的水平，并与３０例正常人进行比较。结果（１）糖尿病组血浆ＴＭ水平明显高于正常对照组（Ｐ＜０．００１），其中临床糖尿病肾病组血浆ＴＭ水平明显高于早期糖尿病肾病组（Ｐ＜０．００１）及尿白蛋白正常的糖尿病组（Ｐ＜０．０１）；（２）血浆ＴＭ水平与尿白蛋白排泄率、ＥＴ水平呈显著正相关（ｒ＝０．５３９０和０．５６５０，Ｐ均＜０．００５）。结论血浆ＴＭ水平测定对２型糖尿病性肾病的早期诊断和病情分析有重要的临床价值。
Objective To measure the plasma levels of thrombomodulin (TM) in patients with diabetic nephropathy and to study the significance of TM in the pathogenesis of microangiopathy. Methods The levels of plasma TM were measured by ELISA in 30 normal controls (NC group) and 58 cases with type 2 diabetes mellitus (DM group), including 10 cases without albuminuria (SDM group), 29 cases with microalbuminuria (EDN group) and 19 cases with macroalbuminuria (CDN group).Plasma endothelin(ET)levelsweremeasuredbyRAST simultaneously. Results The levels of plasma TM were markedly elevated in DM, SDM, EDN and CDN groups than in NC group (P<0.001, 0.05, 0.001 and 0.001, respectively). The plasma TM levels in CDN group were significantly higher than those inSDMandEDN groups (P=0.003 and P<0.001, respectively). There was a positive correlation between plasma TM and urinary albumin excretion rate (r=0.5390,P<0.005), and between plasma TM and plasma ET (r=0.5650, P<0.005) in groups with diabetic nephropathy. Conclusions The measurementofplasmaTMisuseful inevaluatingtheearlydiagnosisandseverityintype2 diabetic nephropathy.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
1999年第1期44-46,共3页
Chinese Journal of Endocrinology and Metabolism
