摘要
目的探讨胸腺素α原对老龄鼠免疫功能及甲状腺激素分泌的调节作用。方法采用分光光度法检测血清溶血素和抗体形成细胞；ＭＴＴ法检测淋巴细胞转化；放免法检测血清甲状腺激素（Ｔ３、Ｔ４及ＴＳＨ）；并称小鼠胸腺、脾脏重量，计算相应指数。结果与对照组相比，胸腺素α原可明显提高胸腺及脾脏指数；促进血清溶血素的分泌，并提高抗体形成细胞水平；促进淋巴细胞转化；促进血清Ｔ３、Ｔ４分泌，降低ＴＳＨ的分泌。结论胸腺素α原不仅具有免疫刺激活性，也可调节Ｔ３、Ｔ４、ＴＳＨ的合成分泌。
Objective To detect the effect of prothymosin α on regulation of immune function and secretion of thyroid hormones in aged mice. Methods Twenty four 15 month old female mice were divided into two groups: one treated for 21 days with prothymosin α intraperitoneally while the other with physiological saline. On 17th day, the two groups were all immunized with sheep red blood cell. After they were sacrificed, serum hemolysin and antibody performing cells (PFC) of splenocytes were determined by spectrocolorimetry; serum T 3, T 4 and TSH by radioimmunoassay, lymphocyte transformationbyMTTmethod.The thymus glands and spleens were weighted to count their corresponding indices. Results Compared with the control group, prothymosin α significantly increased the levels of serum hemolysin, PFC of splenocytes, serum T 3 and T 4 and the thymic and splenic indices. However, itmarkedlydecreased the level of serum TSH. Conclusion Prothymosin α has an immunostimulatory activity, besides, it is also involved in the synthesis and secretion of T 3, T 4 and TSH.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
1999年第1期35-37,共3页
Chinese Journal of Endocrinology and Metabolism
