摘要
目的探讨非胰岛素依赖型糖尿病（ＮＩＤＤＭ）患者血清血管紧张素转换酶（ＳＡＣＥ）水平及其与各种慢性并发症的关系。方法６７例ＮＩＤＤＭ患者用紫外法测定ＳＡＣＥ水平。结果ＮＩＤＤＭ全组ＳＡＣＥ为（３３９±１２４）Ｕ／Ｌ，明显高于正常人［（２８．１±５．７）Ｕ／Ｌ］，Ｐ＞００１。其中超出正常范围（３９５Ｕ／Ｌ）者１８例，占２７％；糖尿病肾病（ＤＮ）者（３０例）ＳＡＣＥ更高［（４２６±１０．６）Ｕ／Ｌ］，而无ＤＮ者［３７例，（２６９±５．７）Ｕ／Ｌ］与正常人无异。结论ＮＩＤＤＭ患者ＳＡＣＥ升高与病程、ＤＮ、视网膜病变（ＤＲ）、神经病变、心血管病变等慢性并发症有关。为临床应用ＡＣＥ抑制剂防治糖尿病慢性并发症提供部分依据。
Objective\ The Relation between serum angiotensin
converting enzyme(SACE) and NIDDM was studied.Methods\ The SACE level was measured
with ultraviolet method in 67 patients.Result\ the mean level of (33.9±12.4)U/L was
signifficantly higher than normal level [(28.1±5.7)U/L, P <0 01],18(27%) hoving an elevation
of SACE (>39.5U/L,2SD above the mean level in the healthy controls). The SACE level of 30
patients with diabetic nephropathy (DN) was much higher [(42.6±10.6)IU/L],but that of 37
patients without SN[(26.9±5.8)U/L] was not significantly different from normal.Conclusion\ The
associatic assay of warious coplications of NIDDM with elevations of SACE was shown that
elevations of SACE was significantly associsted with DN,retinopathy,cardiovascular disencse,It
give some basis for using ACE inibitor in treating complications of diabetes mellitus.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
1999年第4期209-210,共2页
Chinese Journal of Practical Internal Medicine
关键词
NIDDM
糖尿病
血管紧张素
转换酶
并发症
IDDM Angiotensin-converting enzyme(ACE)\ Diabertic nephropathy(DX)\ Diabetic
retinopathy(DR)
