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高尿酸血症——心血管事件的独立危险因素 被引量:15

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摘要 尿酸是嘌呤分解代谢的最终产物。大量流行病学证据和临床研究显示,高尿酸血症与心血管事件的发病率及死亡率相关,是心血管事件的独立危险因素。高尿酸血症导致氧化应激、内皮功能障碍、血管平滑肌细胞增殖,发挥了重要的病理生理作用。该文就高尿酸血症对心血管事件的影响和发生机制加以综述,并介绍黄嘌呤氧化酶抑制剂和氯沙坦等一些降血清尿酸药物在治疗心血管疾病方面的临床应用。
出处 《国际心血管病杂志》 2010年第4期229-231,共3页 International Journal of Cardiovascular Disease
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