摘要
核因子ｋＢ与热休克蛋白７０均是蛋白质，前者活化后进入细胞核调节相关基因表达，后者是机体在某些应激状态下才合成以维持细胞功能。本文采用免疫组织化学ＳＰ法对４０例星形细胞瘤标本进行分析，分别计算核因子ｋＢ与热休克蛋白７０的核阳性率，并进行相关分析，发现热休克蛋白７０的核阳性率随核因子ｋＢ核阳性率的变化而变化，二者呈正相关关系。
Objective:To detect whether there are some relationship between the activity of nuclear factor kappa B(NF-kB)and the expresion of heat shock protein 70(HSP70).Methods:40 formalin fixed astrocytoma specimen were examined by immunohistochemistry SP methods with anti-P65 and anti-HSP70.Results:The positive nuclear staining of NF-kB/P65 ranges from 10% to 80% wile that of HSP70 ranges from 15% to 100%,the correlation coefficient was 0 79.Conclusion:There is some quantitative correlation between NF-kB and HSP70.
出处
《华西医学》
CAS
1999年第1期31-32,共2页
West China Medical Journal
