摘要
目的：探讨红霉素的抗哮喘气道炎症作用。方法：对２６例发作期过敏性哮喘患者肺泡巨噬细胞（ＡＭ）进行体外分别加红霉素、地塞米松、生理盐水（空白对照组）培养，测定培养上清液中血栓素Ｂ-２（ＴＸＢ_２）、肿瘤坏死因子－α（ＴＮＦ－α）、白介素－８（ＩＬ－８）水平。结果：加红霉素培养组培养上清液中ＴＮＦ－α、ＩＬ－８水平明显低于空白对照组，ＴＸＢ_２水平与空白对照组差异无显著性。地塞米松组培养上清液中ＴＸＢ２、ＴＮＦ－α水平低于空白对照组，ＩＬ－８与空白对照组差异无统计学意义。结论：红霉素可通过抑制哮喘患者肺泡巨噬细胞分泌ＴＮＦ－α、ＩＬ－８起抗炎作用，且其抗炎作用与地塞米松既交叉又互补。
Objective:To investigate the anti-airway-inflammation effect of erythromycin in asthma , Method: 26 patients with atopic asthma on attack were enrolled in this study. The alveolar macrophages (AM ) from asthmatic patient were incubated with erythromycin, dexamethasone and normal saline in vitro respetively. The concentrations of TXB_2 TNF-α and IL-8 in culture supernatants were measured. Results: The levels of TNLF-α and IL-8 in culture supernatants of AM treated with erythromycin were significantly lower than placebo group. The levels of TNF-α and TXB_2 in culture supernatants of AM treated with dexamethasone were significantly lower than placebo group. Conclusion: Erythromycin might have anti- inflammatory effect through inhibiting TNF-α and IL-8 production by alveolar macrophages, and effect of erythromycin was somewhat similar to dexamethasone.
出处
《天津医药》
CAS
1999年第2期70-71,共2页
Tianjin Medical Journal
