摘要
目的：研究缺氧引起的血管收缩是否与血管内皮细胞释放内皮素（ＥＴ）有关．方法：９５％Ｏ２＋５％ＣＯ２混合气体换成９５％Ｎ２＋５％ＣＯ２引起急性缺氧，描记猪基底动脉环的张力变化．结果：在基础张力条件下和由ＥＴ３ｎｍｏｌ·Ｌ－１引起收缩时，缺氧分别使基底动脉张力增加０２１ｇ±００８ｇ和０２４ｇ±００９ｇ．当ＥＴ浓度从１００ｎｍｏｌ·Ｌ－１增加到３００ｎｍｏｌ·Ｌ－１时，动脉的张力不进一步增加，此时急性缺氧仍使张力进一步增加０１６ｇ±０１０ｇ．过氧化氢酶８００，２４００ｋＵ·Ｌ－１明显降低缺氧引起的收缩，抑制率分别为３３％±７％和４７％±９％．
AIM: To study whether anoxia induced vaso￣con￣stric￣tion was related to the release of endothelin (ET). METHODS: Acute anoxia was induced by gassing the organ chamber with 95 % N 2+ 5 % CO 2. Changes in tension of porcine basilar arterial ring was recorded. RESULTS: Anoxia induced increases in tension were 0 21 g±0 08 g and 0 24 g±0 09 g under basal tension and during ET 3 nmol·L -1 induced contractions, respectively. In the rings tension did not further augment following the increase of ET from 100 to 300 nmol·L -1 , acute anoxia did cause further increase in tension of 0 16 g± 0 10 g ( n =4). Catalase 800 and 2400 kU·L -1 decreased the anoxia induced contraction, with inhibitory rate of 33 % ± 7 % and 47 % ± 9 % , respectively. CONCLU￣SION: Anoxia induced vaso￣cons￣tric￣tion was related to release of hydrogen peroxide from endothelial cells.
出处
《中国药理学报》
CSCD
1999年第1期43-46,共4页
Acta Pharmacologica Sinica
