摘要
目的:本文探讨以烟叶为原料,制备高纯度茄尼醇的新工艺。方法:将预处理过的烟叶经混合溶剂提取、皂化得茄尼醇浸膏;将该浸膏溶解、脱蜡,于-18℃下结晶得到初步精制的茄尼醇;最后经大孔树脂(YPR-Ⅱ、D-1300、HZ-816、HZ-802)吸附纯化。结果:混合溶剂为石油醚-乙醇,体积比为1∶4,料液比为1∶12,茄尼醇得率最高,经皂化得纯度为32%茄尼醇,再经结晶得到茄尼醇纯度达63.4%,最后通过大孔树脂吸附纯化得到纯度为93.6%以上的茄尼醇。结论:通过一般溶剂提取、皂化、结晶、大孔树脂吸附纯化等工艺,最终可得纯度高于现有技术获得的茄尼醇。
AIM：To discuss the technique for preparing high-purity solanesol from tobacco. METHODS：The pre-treated tobacco leaves were extracted with mixed solvent of petroleum ether and ethanol,and saponified to obtain solanesol extract; The solanesol extract got through redissolution and dewaxing,then crystallized in the temperatare of -18 ℃; Finally purified by macroporous resin（YPR-Ⅱ,D-1300,HZ-816,HZ-802）. RESULTS：The ratio of mixed solvent of petroleum ether and ethanol was 1 ∶ 4,ratio of liquid to materials was 1 ∶ 12,solanesol purity was about 32% after saponification,then crystallization made the purity up to 63. 4% ,finally purified through macroporous resin,the solanesol purity reached above 93. 6%. CONCLUSION：Through the general solvent extraction,saponification,crystallization and macroporous resin adsorption process,the solanesol purity of the product reaches higher than commonly expected values.
出处
《中成药》
CAS
CSCD
北大核心
2010年第7期1128-1131,共4页
Chinese Traditional Patent Medicine
关键词
烟叶
茄尼醇
皂化
纯化
大孔树脂
tobacco
solanesol
saponification
purity
macroporous resin
