期刊文献+

登革病毒NS1蛋白研究进展

Progress in research on NS1 protein of dengue viruses
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摘要 登革病毒感染可引起登革热及登革出血热/登革休克综合征,是热带与亚热带地区重要的公共卫生问题。登革病毒非结构蛋白NS1(nonstructural protein1),在病毒感染、复制及病理过程中起着重要作用。该文综述了近年来登革病毒非结构蛋白NS1结构与功能的研究进展。 Infections with dengue virus(DENV)can result in dengue fever/ dengue hemorrhagic fever/ dengue shock syndrome(DF/DHF/DSS),which is a significant public health problem in tropical and subtropical regions.Nonstructural protein 1(NS1)of DENV plays an important role in viral replication and pathogenesis.The progress in research on the function of the NS1 protein of dengue virus is reviewed in this paper.
出处 《军事医学科学院院刊》 CSCD 北大核心 2010年第3期286-289,共4页 Bulletin of the Academy of Military Medical Sciences
关键词 登革病毒 病毒非结构蛋白质类 功能 结构 dengue virus viral nonstructural protein function structure
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参考文献29

  • 1World Health Organization.Dengue and dengue haemorrhagic fever[EB/OL].2009.http://www.who.int/mediacentre/factsheets/fs117/en/.
  • 2Wallis TP,Huang CY,Nimkar SB,et al.Determination of the disulfide bond arrangement of dengue virus NS1 protein[J].J Biol Chem,2004,279(20):20729-207241.
  • 3Pryor MJ,Wright PJ.Glycosylation mutants of dengue virus NS1 protein[J].J Gen Virol,1994,75 (Pt 5):1183-1187.
  • 4Leblois H,Young PR.Maturation of the dengue-2 virus NS1 protein in insect cells:effects of downstream NS2A sequences on baculovirus-expressed gene constructs[J].J Gen Virol,1995,76 (Pt 4):979-984.
  • 5Falgout B,Chanock R,Lai CJ.Proper processing of dengue virus nonstructural glycoprotein NS1 requires the N-terminal hydrophobic signal sequence and the downstream nonstructural protein NS2a[J].J Virol,1989,63(5):1852-1860.
  • 6Henchal EA,Putnak JR.The dengue viruses[J].Clin Microbiol Rev,1990,3(4):376-396.
  • 7Alcon-LePoder S,Drouet MT,Roux P,et al.The secreted form of dengue virus nonstructural protein NS1 is endocytosed by hepatocytes and accumulates in late endosomes:implications for viral infectivity[J].J Virol,2005,79(17):11403-11411.
  • 8Avirutnan P,Zhang L,Punyadee N,et al.Secreted NS1 of dengue virus attaches to the surface of cells via interactions with heparin sulfate and chondroitin sulfate E[J].PLoS Pathog,2007,3(11):1798-1812.
  • 9Jacobs MG,Robinson PJ,Bletchly C,et al.Dengue virus nonstructural protein 1 is expressed in a glycosyl-phosphatidylinositol-linked form that is capable of signal transduction[J].FASEB J,2000,14(11):1603-1610.
  • 10Mackenzie JM,Jones MK,Young PR.Immunolocalization of the dengue virus nonstructural glycoprotein NS1 suggests a role in viral RNA replication[J].Virology,1996,220(1):232-240.

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