摘要
通过测定药物颗粒界面Zeta电位和平均粒径,研究了聚合物分散剂苯乙烯磺酸聚合物钠盐(GY-D08)用量、pH和盐离子对氟虫脲水悬浮剂分散稳定性的影响,研究结果表明,分散剂GY-D08的加入量与水悬浮剂分散效果密切相关,制备质量分数为5%氟虫脲水悬浮剂的GY-D08最佳用量为2%,GY-D08用量过多或过少都会使分散效果下降;pH影响分散剂GY-D08在水中的电离能力,当pH=9时,GY-D08分子完全电离,能为颗粒提供较大的静电位阻,水悬浮剂分散稳定性最好;Mg2+或Ca2+压缩颗粒界面的双电层,降低Zeta电位,使颗粒因带电量减少而聚结,导致水悬浮剂分散稳定性变差,且Mg2+或Ca2+浓度愈大,其分散稳定性愈差;当离子浓度相同时,Ca2+压缩双电层的能力比Mg2+强,添加Ca2+后的水悬浮剂的分散稳定性更差.
The effects of the mass fraction of GY-D08,pH value and inorganic ions on the dispersion stability of flufenoxuron suspension concentrate were studied by means of measuring zeta potential and average size analysis. The dispersion stability of suspension concentrate was closely related to the mass fraction of GY-D08; the optimum mass fraction of GY-D08 was 2% （ mass fraction） when preparing 5% （ mass fraction） flufenoxuron suspension concentrate with GY-D08; the dispersion stability would be worse on condition that GY-D08 was overfull or lacking. pH affected the ionization of GY-D08 in water,at the pH value of 9 the dispersion stability of suspension concentrate was best on account of strong electrostatic exclusion and steric hindrance which was provided by completely ionizing of the molecules. Mg2 ＋ or Ca2 ＋ was able to decrease Zeta potential by compressing the electronic double layer thickness of particles surface,which could lead to particles aggregation due to the reduction of electric quantity and ultimately make the dispersive effect of suspension concentrate worse,then the higher the content of Mg2 ＋ or Ca2 ＋ was,the worse the dispersion stability of flufenoxuron suspension concentrate was. If the ions concentration were the same,the capacity of compressing the electronic double layer thickness of particles surface by Ca2 ＋ was stronger than Mg2 ＋ ,the dispersion stability of suspension were worse after adding Ca2 ＋ .
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2010年第7期1386-1390,共5页
Chemical Journal of Chinese Universities
基金
山东省自然科学基金(批准号:ZR2009DM032)资助
关键词
氟虫脲
水悬浮剂
聚合物分散剂
ZETA电位
平均粒径
分散稳定性
Flufenoxuron
Suspension concentrate
Copolymer dispersant
Zeta potential
Average size
Dispersion stability
