摘要
【目的】探讨原始神经外胚瘤（ＰＮＥＴ）与其它恶性小细胞肿瘤的鉴别要点。【方法】应用免疫组化ＳＰ法对１４例ＰＮＥＴ进行免疫组化标记，同时结合临床病理资料进行分析。【结果】１４例ＰＮＥＴ中，除胸壁３例外，其余的均沿身体纵轴分布，为一界限性肿块，瘤细胞密集呈巢状排列，常被致密纤维组织分隔成分叶状或腺泡状，可见神经性玫瑰花形物形成；免疫组化神经性标记至少２项以上阳性。【结论】临床病理学观察结合免疫组化，在ＰＮＥＴ与其它恶性小细胞肿瘤的鉴别诊断中有重要意义。
Objective To investigate the differential diagnosis between primitive neuroectodermal tumor(PNET) and other malignant small cell tumors. Methods In combination with analysis of clinicopathological data,paraffin embedded biopsies from 14 patients with PNET were studied immunohistochemically. Results It was found that this tumor frequently developed along the longitudinal axis of the body excepting 3 cases in chest and formed localized mass.The neoplastic cells were arranged in nests,lobules or alveoli separated by dense fibrous tissues.Homer-Wright rosettes were often seen.Immunohistochemically PNET expressed at least more than two positive neural markers. Conclusions It is suggested that clinicopathological investigation in combination with immunohitochemical observation shows important significance in the differential diagnosis between PNET and other malignant small cell tumors.
出处
《湖南医学》
1999年第1期10-11,共2页
Hunan Medical Journal
关键词
原始神经外胚瘤
病理分析
免疫组织化学
neoplasms,embronal and mixed
pathology,clinical
immunohistochemistry
