摘要
目的探讨核苷类药物停药后慢性乙型肝炎复发病例的临床特点。方法观察25例服用核苷类药物治疗的慢性乙型肝炎患者停药后的临床治疗过程。结果 25例患者中,核苷类药物治疗疗程不足12个月8例(32.0%);患者自行停药23例(92.0%),在医师指导下停药2例(8.0%);17例(89.5%)患者停药后6个月内复发;停药时19例(76.0%)患者HBVDNA<1.00×103copies/ml,其中病情复发时17例(89.5%)患者HBVDNA>1.00×103copies/ml;肝硬化患者和慢性乙型肝炎患者停药后病情复发时加重的比率分别为91.7%和53.8%,两者差异有统计学意义(P<0.05);4例(16.0%)患者死亡。结论大部分服用核苷类药物抗病毒治疗的乙型肝炎患者停药后病情复发,部分患者病情加重甚至死亡。停药后病情复发病例应再次给予抗病毒治疗。
Objective To investigate the clinical features of the patients with chronic hepatitis B after withdrawal of nucleoside analogs.Methods The clinical process of 25 patients with chronic hepatitis B after withdrawal of nucleoside analogs was observed.Results The course of treatment with nucleoside analogs was12 months in 8 cases（32.0%）.Patients stop taking 23 cases（92.0%）,under the guidance of the physician discontinued in 2 cases（8.0%）;17 cases（89.5%）patients within 6 months after treatment relapse;The HBV DNA level in serum was1.00×103copies/ml in 19 cases（76.0%）patients at the time of withdrawal of nucleoside analogs,but the HBV DNA level in serum was1.00×103copies/ml in 17 cases（89.5%）patients after recurrence of hepatitis B.The deterioration rate were 91.7% and 53.8% respectively in the group of liver cirrhosis and in the group of chronic hepatitis B after withdrawal of nucleoside analogs,there was significant difference between them（P0.05）;4 cases（16.0%）died.Conclusions Recurrence of hepatitis B may occur in most patients with chronic hepatitis B after withdrawal of nucleoside analogs,and deterioration of liver function may occur in some patients and a few patients may die.Secondary antiviral therapy should be applicated if recurrence of hepatitis B occur in patients with chronic hepatitis B after withdrawal of nucleoside analogs.
出处
《临床合理用药杂志》
2010年第14期28-29,共2页
Chinese Journal of Clinical Rational Drug Use
关键词
乙型肝炎
慢性
核苷类药物
停药
复发
Chronic hepatitis B
Nucleoside analogs
Withdrawal
Recurrence
