摘要
目的考察几种非促渗剂方法对氟比洛芬凝胶经皮渗透的影响。方法采取提高氟比洛芬浓度、制备了氟比洛芬羟丙基-β-环糊精包合物、氟比洛芬单乙醇胺盐和钠盐来改善氟比洛芬的经皮渗透。结果含药质量分数在2%以下时,氟比洛芬的经皮渗透速率随含量增加而升高。随着羟丙基-β-环糊精浓度的增加,氟比洛芬的经皮渗透速率降低。氟比洛芬单乙醇胺盐经皮渗透速率略高于氟比洛芬,而氟比洛芬钠盐经皮渗透速率远低于氟比洛芬。结论增加药物含量、合成氟比洛芬单乙醇胺盐对氟比洛芬有渗透促进作用,羟丙基-β-环糊精包合以及合成氟比洛芬钠盐对氟比洛芬有渗透抑制作用。
Objective To study the effect of several methods without penetration enhancer in transdermal permeation of flurbiprofen.Methods The concentration of flurbiprofen was increased and the monoethanolamine salt,sodium salt and hydroxypropyl-β-cyclodextrin inclusion complex of flurbiprofen were prepared to promote the transdermal permeation of flurbiprofen.Results When the drug concentration was less than 2%（w）,the flux of flurbiprofen was increased with the increase of the concentration of flurbiprofen.The flux of flurbiprofen decreased with the increase of hydroxypropyl-β-cyclodextrin concentration.The flux of flurbiprofen monoethanolamine salt was slightly higher than that of flurbiprofen,and the flux of flurbiprofen sodium was much lower than that of flurbiprofen.Conclusions The transdermal permeation of flurbiprofen is increased by the increase of drug concentration and preparation of the monoethanolamine salt of flurbiprofen;the transdermal permeation of flurbiprofen is inhibited through the preparation of the sodium salt and hydroxypropyl-β-cyclodextrin inclusion complex of flurbiprofen.
出处
《沈阳药科大学学报》
CAS
CSCD
北大核心
2010年第7期516-519,529,共5页
Journal of Shenyang Pharmaceutical University
关键词
经皮渗透
氟比洛芬单乙醇胺
氟比洛芬钠
羟丙基-Β-环糊精
药物含量
transdermal permeation
hydroxypropyl-β-cyclodextrin
flurbiprofen sodium salt
flurbiprofen monoethanolamine salt
drug content
