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早期非小细胞肺癌组织中miR-106a的表达变化及意义 被引量：8

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摘要 目的观察早期非小细胞肺癌(NSCLC)组织中微小RNA-106a(miR-106a)的表达变化,并探讨其临床意义。方法采用实时定量PCR(qRT-PCR)检测52例早期NSCLC患者肿瘤组织及癌旁正常肺组织中的miR-106a。结果早期NSCLC组织中miR-106a的表达量明显高于癌旁正常肺组织(P<0.001),早期NSCLC组织中miR-106a的表达与术后复发和死亡显著相关(P均<0.05)。结论早期NSCLC组织中miR-106a高表达。miR-106a检测有助于早期NSCLC的诊断和预后判断。
作者 王欢 翁国星 陈智群 徐驯宇 张积广
机构地区 福建省立医院 武汉协和医院
出处 《山东医药》 CAS 北大核心 2010年第22期51-52,共2页 Shandong Medical Journal
关键词 肺部肿瘤 非小细胞肺癌 微小RNA miR-106a
分类号 R734.2 [医药卫生—肿瘤]
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参考文献9

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同被引文献46

  • 1Guo-Gang Li,Lan Li,Chao Li,Long-Yun Ye,Xiao-Wen Li,Da-Ren Liu,Qi Bao,Yi-Xiong Zheng,Da-Peng Xiang,Li Chen,Jian Chen.Influence of up-regulation of Notch ligand DLL4 on biological behaviors of human gastric cancer cells[J].World Journal of Gastroenterology,2013,19(28):4486-4494. 被引量：12
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引证文献8

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山东医药
2010年 第22期

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