摘要
目的：探讨血浆内皮素（ＥＴ）和血清脂质过氧化物（ＬＰＯ）在脑出血病理过程中的作用及相互关系。方法：测定脑出血急性期（３０例）和亚急性期（３０例）患者血浆ＥＴ和血清ＬＰＯ的水平，并分别与单纯高血压患者（３０例）及正常人（３０例）作对照分析。结果：脑出血急性期血浆ＥＴ〔（１００．６０±３１．０３）ｎｇ／Ｌ〕及血清ＬＰＯ〔（８．５３±１．０１）μｍｏｌ／Ｌ〕水平均高于亚急性期、单纯高血压患者和正常人对照组（Ｐ均＜０．０１），其升高水平与神经功能缺损程度呈正相关，但与出血量不呈直线相关关系；ＥＴ水平变化与出血部位有关，血浆ＥＴ含量与血清ＬＰＯ呈直线相关关系。结论：ＥＴ与ＬＰＯ在脑出血病理过程中具有一定作用。
Objective:To investigate the relationship between plasma endothelin(ET) and serum lipid peroxidation (LPO) in the pathologic process of patients with cerebral hemorrhage.Methods:Plasma ET and LPO levels were measured in 60 patients with cerebral hemorrhage during acute stage and subacute stage,30 patients with simple hypertension and 30 normal volunteers served as controls.Results:It showed that ET and LPO were significantly increased in patients with acute stage ET(100 60±31 03)ng/L;LPO(8 53± 1 01)μmol/L compared with those with subacute stage,simple hypertension,and controls (all P <0 01).Also,ET and LPO levels were positively correlated with the defect degree of nerves,but they had no linear correlation with the degree of hematoma.In addition,changes in ET were related to the site of bleeding,and it had a linear correlation with LPO.Conclusions:ET and LPO play important role in the pathogenesis of cerebral hemorrhage,they may enhance brain damage after bleeding.
出处
《中国危重病急救医学》
CSCD
1999年第3期155-157,共3页
Chinese Critical Care Medicine
关键词
内皮素
脂质过氧化物
脑出血
急性期
endothelin\ \ lipid peroxidation\ \ cerebral hemorrhage
