摘要
目的：探讨银杏叶制剂对蛛网膜下腔出血（ＳＡＨ）后脑水肿的防治作用。方法：应用非开颅性大鼠ＳＡＨ模型，检测蛛网膜下腔出血前及出血后１，６及２４小时时脑组织含水率和电解质（Ｎａ＋和Ｋ＋）含量的变化，并观察银杏叶制剂和尼莫地平对其影响。结果：单纯ＳＡＨ组术后６小时和２４小时脑组织含水率（８０．４１％±０．７６％和８２．８１％±０．５５％）较术前含水率（７７．６０％±０．５５％）增加；Ｎａ＋含量术前（３５５．６±４５．８）μｍｏｌ／ｇ，术后６小时和２４小时分别增至（４６１．８±４６．７）μｍｏｌ／ｇ与（６８４．４±４８．０）μｍｏｌ／ｇ；Ｋ＋含量于术后６小时和２４小时〔（５３０．３±２９．３）μｍｏｌ／ｇ与（４６１．６±５２．１）μｍｏｌ／ｇ〕较术前〔（５８６．９±２４．６）μｍｏｌ／ｇ〕减少（Ｐ均＜０．０１）。在尼莫地平组和银杏叶制剂组，术后６小时时含水率（７９．０６％±０．６８％与７８．６６％±０．６１％）较单纯ＳＡＨ组为低（Ｐ＜０．０５或Ｐ＜０．０１），２４小时时含水率（８０．６０％±０．５３％与７９．５１％±０．７２％）亦低于单纯ＳＡＨ组（Ｐ＜０．０５或Ｐ＜０．０１），而银杏叶制剂组又低于尼莫地平组（Ｐ＜０?
Objective:To investigate the therapeutic effects of Ginkgo biloba extract on brain edema following subarachnoid hemorrhage(SAH).Methods:A noncraniotomy model of SAH was reproduced in Wistar rats,and animals were divided into pure SAH,nimodipine treated and Ginkgo biloba extract treated groups.Brain water and electrolyte contents were determined in animals prior to operation and at 1,6 and 24 hours after induction of SAH.Results:At 6 and 24 hours after SAH,brain water and sodium contents significantly increased ,while potassium contents decreased compared with baseline values respectively brain water: 80 41%±0 76% and 82 81%±0 55% vs.77 60%±0 55%;soduim:(461 8±46 7)μmol/g and (684 4± 48 0)μmol/g vs.(355 6±45 8)μmol/g;potassium:(530 3±29 3)μmol/g and (461 6±52 1)μmol/g vs. (586 9±24 6)μmol/g ,all P <0 01 .In nimodipine and Ginkgo biloba extract treated groups,brain water contents were lower than that in SAH group at 6 and 24 hours respectively 6 hours:79 06%±0 68% and 78 66% ±0 61%; 24 hours:80 60%±0 53% and 79 51%±0 72%, P <0 05 or P <0 01 ,whereas it was lower in Ginkgo biloba extract treated group than that in nimodipine treated group ( P <0 05).Moreover,sodium contents markedly decreased in two treated groups compared with SAH group at 6 and 24 hours 6 hours:(408 8±22 1)μmol/g and (419 1±50 3)μmol/g;24 hours:(529 6±54 9)μmol/g and (507 4±31 2) μmol/g, P <0 05 or P <0 01).In addition,potassium contents were higher in treated groups (516 0±34 6)μmol/g and (501 5±20 5)μmol/g,resectively than that in SAH group at 24 hours (both P <0 05). Conclusions :Ginkgo biloba extract is effective in relieving brain edema after SAH.
出处
《中国危重病急救医学》
CAS
CSCD
1999年第3期148-150,共3页
Chinese Critical Care Medicine
基金
山东省科委基金
关键词
蛛网膜下腔出血
脑水肿
银杏叶制剂
尼莫地平
subarachnoid hemorrhage\ \ brain edema\ \ Ginkgo biloba extract nimodipine
