摘要
本文对12例乙型脑炎(以下简称乙脑)患者试用内源性阿片多肽拮抗剂纳洛酮(naloxone)治疗,除1例无效外,其余均获得不同程度的症状改善。用药后24小时内,11例患者神志明显改善甚至清醒,5例反复抽搐者抽搐停止,2例中枢性呼吸衰竭患者呼吸衰竭曾一度明显改善.治疗结果证实乙脑患者血及脑脊液(CSF)中升高的内源性阿片多肽参与乙脑发病机制并为乙脑的对症治疗提供一种新的治疗方法.
We treated 12 patients with epidemic encephalitis-B using naloxonea special angonist of endogenous opiate peptides.The result proved effective in all patients except one,consciousness improved signifcantly and help to wake up in 24 hours;convulsions were controlled in 5 patients,the central respiratory failure improved significantly in 2 patients.The study suggested that elevated levels of endogenous opiate peptides in blood and CSF were involved in pathogenesis of epidemic encephalitis-B and naloxone is an effective therapy.
出处
《上海第二医科大学学报》
CSCD
1990年第2期116-118,共3页
Acta Universitatis Medicinalis Secondae Shanghai
关键词
乙型脑炎
纳洛酮
naloxone
endogenic opiate peptides
angonist action
epidemic encephalitis-B
