摘要
目的观察长春瑞滨联合卡培他滨对蒽环、紫杉类药物治疗无效的复发转移性乳癌的疗效及毒性。方法蒽环、紫杉类药物治疗无效的复发转移性乳癌病人33例,给予长春瑞滨25 mg/m2,第1、8天,采用深静脉穿刺置管技术静脉滴注;卡培他滨每天1 000 mg/m2,分2次餐后30 min温水送服,连用14 d,间隔7 d,21 d为1周期。进展病例2周期后停止治疗;而有效和稳定病例均在治疗4周期后评价疗效。结果完全缓解(CR)1例,部分缓解(PR)6例,好转(MR)8例,稳定(SD)12例,进展(PD)6例,有效率达45.5%。常见的不良反应为骨髓抑制、恶心、呕吐和手足综合征等。结论长春瑞滨联合卡培他滨对紫杉或蒽环类药物治疗无效的转移性乳癌有较好的疗效,毒性可以耐受。
Objective To observe the efficacy and toxicity of combination chemotherapy with vinorelbine and capecitabine for advanced and recurrent or metastatic breast cancer. Methods Thirty-three breast-cancer patients who were either refractory to antracene or recurrent were offered vinorelbine 25 mg/m2 on day 1 and day 8,intravenously;capecitabine 1 000 mg/m2,orally,twice a day,30 min after meals,continuous for 14 days followed by interval of 7 days.One cycle was 21 days.For the aggravated,the therapy discontinued after two cycles;for responded and stable ones,the efficacy was assessed after four cycles of treatment.Results The outcomes were as follows： complete remission（1 case）,partial remission（6）,improvement（8）,stable（12）,aggravation（6）,the effective rate being 45.5%.The common side effects seen were myelosuppression,nausea,vomiting,and hand-foot syndrome. Conclusion Combination of vinorelbine and capecitabine is effective for metastatic breast cancers unresponsive with taxanes or anthracyclines therapy.The adverse reactions were tolerated.
出处
《齐鲁医学杂志》
2010年第5期389-390,393,共3页
Medical Journal of Qilu
