摘要
目的探讨p16、雌激素受体(ER)及孕激素受体(PR)在不同程度宫颈病变组织中的表达及与临床病理的关系。方法采用免疫组化SP法染色观察p16、ER及PR在117例宫颈鳞癌、宫颈上皮内瘤变(CIN)及正常宫颈组织中的表达情况。结果p16、ER及PR在宫颈鳞癌组中的阳性表达率分别为100%,7%和4%;在CINⅢ级组中的阳性表达率分别为79%,12%和8%;在CINⅡ级组中的阳性表达率分别为77%,41%和14%;在CINⅠ级组中的阳性表达率分别为76%,69%和52%;正常对照组p16阴性表达,ER、PR表达率为100%,93%。宫颈鳞癌、CINⅢ级、CINⅡ级及CINⅠ级组织中p16、ER及PR阳性表达率与正常对照组比较有显著性差异(P均<0.01)。结论p16与宫颈鳞癌、CIN的发生、发展密切相关;p16的升高与宫颈病变程度呈正相关。
Objective It is to explore the expression of p16,estrogen receptor（ER） and progesterone receptor（PR） in cervix diseases with different degrees and its relationship with clinical pathology.Methods SP method of immunohistochemistry was used to detect the expression of p16,ER and PR in 117 cases of cervix squamouse carcinoma cervix intraepithelial neoplasm（CIN） and normal cervix tissue sections.Results The positive rates of p16,ER and PR in squamous cell carcinoma of cervix were 100%,7% and 4% respectively,in CIN Ⅲ degree were 79%,12% and 8%,in CINⅡ degree were 77%,41% and 14%,in CIN I degree were 76%,69% and 52% respectively.100%,93% positive expression rates of ER,PR and negative rate of p16 were found in normal control gorup.There were significant differences between cervix disease groups and normal control group in the positive expression rates of the above genes（P均〈0.01）.Conclusion p16,ER,PR gene correlate closely with the occurrence and development of cervix carcinoma and CIN,p16 has positive relation to the grade of cervix lesions.
出处
《现代中西医结合杂志》
CAS
2010年第22期2744-2745,2828,共3页
Modern Journal of Integrated Traditional Chinese and Western Medicine
关键词
鳞状细胞癌
宫颈上皮内瘤变
P16
ER
PR
squamous cell carcinoma
cervical intraepithelial neoplasia
p16
ER
PR
