摘要
目的探讨高锝[99mTc]酸钠(99mTcO4-)和99mTc-MIBI联合核素显像在多发性甲状腺结节伴甲状腺癌中的价值。方法对52例临床怀疑为多发性甲状腺结节伴甲状腺癌的患者,采用GE Millennium单探头MPRSPECT,分别进行99mTcO4-甲状腺静态显像和99mTc-MIBI双时相显像,将显像结果与手术病理结果进行对照。结果 52例患者中,病理结果显示共有甲状腺结节126个,其中恶性结节40个、良性结节86个;99mTcO4-甲状腺静态显像均显示为多发结节样改变,共发现甲状腺结节103个,其中热结节8个,温结节20个,凉结节35个,冷结节40个。40个恶性甲状腺结节中,15个有明显的99mTc-MIBI摄取,其中凉结节2个,冷结节13个;86个良性甲状腺结节中,32个有明显的99mTc-MIBI摄取,其中温结节3个,凉结节14个,冷结节15个。99mTcO-4和99mTc-MIBI联合核素显像诊断多发性甲状腺结节伴甲状腺癌的灵敏度为37.50%,特异度为62.79%。甲状腺良恶性结节的联合显像阳性率差异无统计学意义(χ2=0.001,P>0.05)。结论 99mTcO4-和99mTc-MIBI联合核素显像对于多发性甲状腺结节伴甲状腺癌的诊断不具有特异性,其临床应用价值有限。
Objective To explore the value of the ^99mTcO4^- and ^99mTc-MIBI combined imaging in multiple thyroid nodules patients with thyroid cancer. Methods Fifty-two patients suspected multiple thyroid nodules with thyroid cancer underwent ^99mTcO4^- and ^99mTc-MIBI combined imaging and then the results were compared with pathological findings. The GE Millennium single head MPR SPECT was used for static thyroid imaging with ^99mTcO4^- and dual phase imaging with ^99mTc-MIBI. Results A total of 126 thyroid nodules were found pathologically in 52 patients,including 40 malignant and 86 benign nodules. Static thyroid imaging with ^99mTcO4^- showed multiple nodular changes,including 8 hot nodules,20 warm nodules,35 cool nodules and 40 cold nodules. In 40 malignant thyroid nodules,apparent ^99mTc-MIBI uptake were found in 15 nodules,including 2 cool nodules and 13 cold nodules. In 86 benign thyroid nodules,apparent ^99mTc-MIBI uptake were found in 32 nodules,including 3 warm nodules,14 cool nodules and 15 cold nodules. The sensitivity,specificity of the combined imaging was 37.50% and 62.79%,respectively. No statistic difference was found between benign and malignancy thyroid nodules （χ^2=0.001,P〉0.05）. Conclusion ^99mTcO4^- and ^99mTc-MIBI combined imaging is not specific for multiple thyroid nodules in patients with thyroid cancer,the clinical value is limited.
出处
《中国医学影像技术》
CSCD
北大核心
2010年第7期1343-1345,共3页
Chinese Journal of Medical Imaging Technology
基金
国家重点基础研究发展计划(973计划)资助项目(2006CB705705)
教育部教育振兴行动计划特殊专项("985"工程:Ⅱ期)资助项目(985-2-056)
