摘要
目的：探讨不同温度体外循环中血小板血栓栓塞情况。方法：将１８只猪均分为３组行体外循环。Ｉ组，１８℃深低温停循环；Ｉ组，２８℃中度低温体外循环；ＩＩ组，３７℃常温体外循环。用铟１１１标记的自体血小板测定３组心、肺、脑、肝、脾、肾和体外循环设备的血栓栓塞情况。结果：在ＩＩ组和Ｉ组肾脏标记的的血小板含量较Ｉ组高，Ｐ＜０．０１。Ｉ、ＩＩ组标记的血小板在动脉微栓过滤器中的含量也较高，但与Ｉ组差异无显著性（Ｐ＝０．０６）。其他器官和设备３组间差异无显著性。结论：常温体外循环组肾血栓栓塞率较高，可能是灌注流量较高、血液与非生物材料接触机会多而产生较多微血栓所致。常温下肾血流量较高也可增加肾脏栓塞机会。深低温造成的血液粘稠度增高和血管收缩可能是深低温停循环组肾栓塞率高的原因。
Aim:To evaluate the effect of cardiopulmonary bypass at differenc temperatures on thromboembolization.Material and method:Eighteen yorkshire pigs was divided into 3 groups(n=6 each).Group 1 received 18℃ deep hypothermic circulatory arrest.Group 2 received 28℃ moderate hypothermic cardiopulmonary bypass and group 3 with 37℃ normothermic cardiopulmonary bypass.Indium 111 labeled autologous platelet was used to detect thormboembolization in heart,lungs,brain,liver,spleen,kidneys with cardiopulmonary bypass devices.Result:The distribution of Indium 111 labeled platelets was higher in kidneys in group 3 and group 1 than that in group 2(P<0.01).The distribution of Indium 111 labeled platelets in arterial filter was slightly higher also in these 2 groups when compared with group 2 but with no significant difference.There were no significant differentes in other organs in 3 groups.Conclusion:The higher incidence of kidney thromboembolization during normothermic cardiopulmonary bypass might be related to the higher perfusion flow rate,which resulted in higher exposure of blood to nonbioprosthetic devices and production of more microthrombi.The higher flow rate in kidneys under normothermic condition might also bring more microthrombi to kidneys.The higher blood viscosity and vessel constriction caused by deep hypothermia might be related to the higher embolization in kidneys in the deep hypothermic circulatory arrest group.
出处
《中华胸心血管外科杂志》
CSCD
北大核心
1999年第1期42-44,共3页
Chinese Journal of Thoracic and Cardiovascular Surgery
关键词
体外循环
血栓栓塞
血小板
温度
Cardiopulmonary bypass Thrombosis embolism Indium 111 platelet
