摘要
目的 探讨依托咪酯、咪唑安定对离体兔肺动脉的直接效应以及内皮的完整性对其效应的影响。方法 制备内皮完整与去内皮兔离体肺动脉环 ,观察两种药物累积剂量 0 .0 3mmol/ L、0 .1mmol/ L、0 .3mm ol/ L、1.0 m mol/ L、3.0 mm ol/ L 对肺动脉的直接作用及对去甲肾上腺素 (NE)预收缩肺动脉的作用 ;两种药物 1m mol/ L对 NE累积剂量量 -效曲线的影响。结果 两种药物累积剂量对张力正常肺动脉环无明显影响 ;对 NE预收缩肺动脉环有剂量依赖性的舒张作用 ,对完整内皮与去内皮动脉环舒张作用无明显差异 (P>0 .0 5 ) ;两种药物 1m mol/ L 可使 NE累积剂量量 -效曲线呈非平行性的右移 ,高剂量 NE〔(10 - 5～ 10 - 3) mol/ L〕时收缩幅度较 NE对照组明显降低 (P<0 .0 5 )。结论 依托咪酯、咪唑安定对张力正常兔离体肺动脉环无直接作用 ;对 NE预收缩肺动脉的舒张作用呈非内皮依赖性 ,对 NE的肺动脉收缩效应表现非竞争性抑制作用。
Objective To understand the effects of etomidate and midazolam on isolated rabbit pulmonary arteries and the possible interaction with functional endothelium.Methods The pulmonary artery rings were prepared with endothelium intact and endothelium denuded.Direct effects of two drugs cumulative concentration on the baseline tone and that precontracted by NE,and influences of two drugs(1mmol/L)on the cumulative concentration response curves of NE were assessed.Results The cumulative concentrations of two drugs from 0.03mmol/L to 3.0mmol/L had no influences on the baseline tone.The artery rings precontracted by NE were vasodilative with dose dependent and endothlium independent way.Two drugs (1mmol/L) made the cumulative concentration response curves of NE shift to right in nonparalled way,the contractile amplitude of pulmonary artery rings was significantly lower than that of NE control(P<0.05).Conclusion Etomidate and midazolam have no influences on the baseline tone of isolated rabbit pulmonary artery rings,vasodilative responses appear in the artery rings precontracted by NE with endothelium independent way.Two drugs may inhibite the contractile effects of NE on pulmonary artery in non competitive way.
出处
《中华麻醉学杂志》
CAS
CSCD
北大核心
1999年第2期108-110,共3页
Chinese Journal of Anesthesiology
