摘要
目的探讨一氧化氮（ＮＯ）与蛛网膜下腔出血（ＳＡＨ）后缺血性脑损害的关系和银杏叶制剂（ＧＢＥ）的保护作用。方法应用非开颅大鼠模型，对ＳＡＨ组和ＧＢＥ组测量基底动脉（ＢＡ）管径并观察２４ｈ内微区脑血流量（ＣＢＦ）和颅内血清ＮＯ水平动态改变，３ｄ后对海马ＣＡ１区行病理检查。结果ＳＡＨ后ＣＢＦ和血清ＮＯ降低，ＢＡ痉挛，海马ＣＡ１区神经元明显受损。ＧＢＥ使上述改变减轻。结论ＳＡＨ时血清ＮＯ减少是导致缺血性脑损害的重要因素。
Objective To investigate the relationship between nitric oxide (NO) and ischemic brain damage after subarachnoid hemorrhage(SAH) and the protective effects of ginkgo biloba extract (GBE) . Methods Using noncraniotomy wister rat models of SAH,the diameter of basilar artery (BA) was measured in pure SAH group and GBE treated group,the dynamic changes of microregional cerebral blood flow(CBF) and NO levels in intracranial serum were observed within 24 hours.Pathological examination of CA 1 region of hippocampus was carried out 3 days later. Results The reduction in CBF and serum NO level,and spasm of BA occurred after SAH. Neurons of CA 1 region of hippocampus were damaged severely.GBE effectively antagonized the above changes.Conclusion The decrease of serum NO level was an important factor that led to ischemic brain damage after SAH.GBE eased ischemic brain damage by influencing pathological change in serum NO level.
出处
《临床神经病学杂志》
CAS
1999年第1期9-9,共1页
Journal of Clinical Neurology
关键词
蛛网膜下腔出血
脑血管痉挛
银杏叶制剂
Subarachnoid hemorrhage Cerebral vasospasm Ischemic brain damage Nitric oxide Ginkgo biloba extract
