摘要
目的观察阿魏酸钠联合缬沙坦对IgA肾病的治疗疗效。方法将60例IgA肾病患者随机分为治疗组(阿魏酸钠联合缬沙坦组)和对照组(缬沙坦组),治疗一月后观察两组患者的血纤维蛋白原、血肌酐、内生肌酐清除率、24h尿蛋白定量、内皮素水平。结果与对照组相比,治疗组在降低血纤维蛋白原,血清肌酐,内皮素,24h尿蛋白定量,提高内生肌酐清除率等方面优于对照组(P<0.05),对照组内素水平于治疗前后差异无统计学意义(P>0.05)。结论阿魏酸钠联合缬沙坦可有效降低IgA肾病尿蛋白,血清肌酐水平,改善内皮功能及血液高粘状态,对IgA肾病有良好的治疗价值。
Objective To observe the effect of sodium ferulate combined with valsartan for treatment of IgA nephropathy. Methods 60 cases of IgA nephropathy were randomly divided into two groups：the treated group were treated with sodium ferulate and valsartan,the control group were treated just with valsartan. After one monthly treatment,the changes of fibrinogen（FIB） ,serum creatinine（Scr） ,creatinine clearance（Ccr） ,urine protein quantitation in 24 hours（UPQ） and endothelin（ET） were observed. Results The treated group were better than the control group in degrading FIB,Scr,ET,UPQ and raiseing Ccr（P〈0. 05） . ET of control group has no significant change before and after treatment（P〉 0. 05） . Conclusion Sodium ferulate combined with valsartan is reliable for treatment of paitents with IgA nephropathy.
出处
《中国现代药物应用》
2010年第14期15-16,共2页
Chinese Journal of Modern Drug Application
关键词
阿魏酸钠
缬沙坦
IGA肾病
Sodium ferulate
Valsartan
IgA nephropathy
Therapeutical effect
