摘要
目的观察稳心颗粒与美托洛尔联合治疗冠心病心律失常的疗效及安全性。方法 192例冠心病心律失常患者随机分为A、B、C各64例,A组给予稳心颗粒与美托洛尔联合治疗,B组给予稳心颗粒治疗,C组给予美托洛尔治疗,用药4周后观察疗效及不良反应发生率。结果 A组:显效51.6%,有效42.2%,总有效率93.8%,不良反应发生率4.7%;B组则分别为32.8%、39.1%、71.9%和7.8%;C组分别为29.7%、39.1%、68.8%和14.1%。A组显效率和总有效率均明显优于B组和C组(P均<0.001)。B组和C组疗效比较差异无统计学意义(P>0.05)。A组不良反应发生率则明显低于C组(P<0.05)。结论稳心颗粒与美托洛尔联合治疗冠心病心律失常疗效显著,安全性好,具有广阔的临床应用前景。
Objective To observate the therapeutic effect and safety of Wenxin Granule combined with metoprolol treating arrhythmia of coronary heart disease.Methods 192 cases with arrhythmia of coronary heart disease were randomly divided into three groups（64 patients in each group）：A group（Wenxin Granule combined with metoprolol）,B group（Wenxin Granule） and C group（metoprolol） .After four weeks treating,the therapeutic effect and adverse reaction incidence of three groups were compared.Results The excellence rate,effective rate,total effective rate and adverse reaction incidence of A group were 51.6%,42.2%,93.8% and 4.7% respectively.They were 32.8%,39.1%,71.9% and 7.8% respectively in B group.They were 29.7%,39.1%,68.8% and 14.1% respectively in C group.The excellence rate and total effective rate of A group were higher than those in B and C group（all P〈0.001） .The level of Hcy,fasting blood glucose,TG,HDL-L and DBP of A group were higher than those of B group（P〈0.01） .The adverse reaction incidence of A group was lower than that in C group（P〈0.05） .Conclusion The therapeutic effect of Wenxin Granule combined with metoprolol treating arrhythmia of coronary heart disease was notable and safe.
出处
《中国实用医药》
2010年第20期33-35,共3页
China Practical Medicine
关键词
冠心病
心律失常
稳心颗粒
美托洛尔
Coronary heart disease
Arrhythmia
Wenxin Granule
Metoprolol
