摘要
肿瘤是危害人类健康与生命的常见疾病之一,其发病机制至今尚未完全探明。Wnt与Notch信号通路在生物体的生长发育中起着重要的调控作用,同时也都被证实与肿瘤相关。两条通路之间存在着许多直接或间接的串话。在肿瘤的发生发展中,二者间的相互作用取决于不同的组织背景,既可以表现为相互协同,也可以表现为相互拮抗。Wnt与Notch信号通路的串话与肿瘤的关系,在基础与临床肿瘤研究中都具有重大意义。本文对两条信号通路的组成、作用机制、相互作用,以及其串话与肺癌、皮肤癌、乳腺癌、白血病、黑色素瘤等肿瘤疾病间的关系进行了阐述与分析。
Tumor is a common disease that damages the health and life of human beings.The pathogenesis of tumor is still not fully understood.Both Wnt and Notch signaling pathways play an important role in regulating the growth and development of organisms and have been proved to be involved in neoplasms.There exist direct or indirect cross-talks between these 2 pathways.In the genesis and development of tumors,the interaction between Wnt and Notch shows either synergetic or antagonistic effect depending on the type of tissues.Clarification of the cross-talks between Wnt and Notch signaling pathways and its role in tumorgenesis is of great significance in both basic and clinical neoplasm studies.This article reviewed the essential components of Wnt and Notch signaling pathways,the cross-talks between these two pathways and the correlation with the development of the tumors including lung cancer,skin cancer,breast cancer,leukemia,and melanoma.
出处
《国际病理科学与临床杂志》
CAS
2010年第3期255-259,共5页
Journal of International Pathology and Clinical Medicine
