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白介素-17与类风湿关节炎的相关性研究 被引量:5

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摘要 类风湿关节炎(RA)是以关节滑膜炎症为主要表现的自身免疫性疾病,T细胞在RA的发病和进展中起关键性作用,以CD4+效应性T细胞尤为重要。近年来在自身免疫病和过敏原特异性反应研究中发现机体存在一种新的CD4+T细胞亚群,其具有白介素-23(IL-23)依赖性产生IL-17,发挥重要的免疫调节作用,而IL-17是其主要效应分子。
出处 《北京医学》 CAS 2010年第7期573-573,575,共2页 Beijing Medical Journal
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参考文献7

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同被引文献53

  • 1窦锡彬,李凤珍,谭树聪.壮医综合治疗类风湿性关节炎37例[J].广西中医药,2006,29(2):45-46. 被引量:27
  • 2李强,黄宪章,丁海明,庄俊华.类风湿性关节炎患者IL-6水平的变化[J].广东医学,2007,28(5):712-713. 被引量:7
  • 3李强,黄宪章,丁海明,庄俊华.外周血白细胞介素-18与类风湿性关节炎相关性研究[J].实用医学杂志,2007,23(8):1143-1144. 被引量:8
  • 4廖满林,廖穗波,陈霭平,张曲涛,黄彩燕,陈艳珍,胡祖光.类风湿性关节炎患者IL-1α、IL-1β、IL-17及OPG水平变化的临床意义[J].四川生理科学杂志,2007,29(1):37-39. 被引量:3
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  • 7Nakahara H, Song J, Sugimoto Met al. Anti-interleukin-6 receptor anti- body therapy reduces vascular endothelial growth factor production in rheumatoid arthrltis[J]. Arthritis Rheum,2003;48(6) : 1521-1529.
  • 8Diveu C, McGeachy M J, Boniface K et al. IL-27 blocks RORc expres- sion to inhibit lineage commitment of Th17 cells[J]. J Immunol,2009; 182(9) : 5748-5756.
  • 9Wong C K, Chen D P, Tam L S et al. Effects of inflammatory cytokine IL-27 on the activation of fibroblast-like synoviocytes in rheumatoid arthritis[J]. Arthritis Research & Therapy,2010; 12: R129-R143.
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